ID Q3UVX2_MOUSE Unreviewed; 622 AA.
AC Q3UVX2;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 124.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN Name=Tiam1 {ECO:0000313|MGI:MGI:103306};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE23147.1};
RN [1] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE23147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23147.1};
RC TISSUE=Diencephalon {ECO:0000313|EMBL:BAE23147.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
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DR EMBL; AK136856; BAE23147.1; -; mRNA.
DR RefSeq; NP_001139358.1; NM_001145886.1.
DR RefSeq; NP_001139359.1; NM_001145887.1.
DR RefSeq; NP_033410.2; NM_009384.3.
DR AlphaFoldDB; Q3UVX2; -.
DR PeptideAtlas; Q3UVX2; -.
DR DNASU; 21844; -.
DR GeneID; 21844; -.
DR KEGG; mmu:21844; -.
DR AGR; MGI:103306; -.
DR CTD; 7074; -.
DR MGI; MGI:103306; Tiam1.
DR OrthoDB; 25601at2759; -.
DR BioGRID-ORCS; 21844; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Tiam1; mouse.
DR Genevisible; Q3UVX2; MM.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR PANTHER; PTHR46001:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 71..265
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 41..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 70606 MW; 7E1E90ADD0FC0825 CRC64;
MSSLWKIKRK PRVESDRAGD SLYRTLHLST EQVAAFCRSL HEMSPSDSSP SPQDATSPQL
ATTRQLSDAD KLRKVICELL ETERTYVKDL NCLMERYLKP LQKETFLTQD ELDVLFGNLT
EMVEFQVEFL KTLEDGVRLV PDLEKLEKVD QFKKVLFSLG GSFLYYADRF KLYSAFCASH
TKVPKVLVKA KTDTAFKAFL DAQNPRQQHS STLESYLIKP IQRVLKYPLL LRELFALTDA
ESEEHYHLDV AIKTMNKVAS HINEMQKIHE EFGAVFDQLI AEQTGEKKEV ADLSMGDLLL
HTSVIWLNPP ASLGKWKKEP ELAAFVFKTA VVLVYKDGSK QKKKLVGSHR LSIYEEWDPF
RFRHMVPTEA LQVRALPSAD AEANAACEIV HVKSESEGRP ERVFHLCCSS PESRKDFLKS
VHSILRDKHR RQLLKTESLP SAQQYVPFGG KRLCALKGAR PAMSRAVSAP SKSLGRRRRR
LARNRFTIDS DAISASSPEK EPQQPAGGGD TDRWVEEQFD LAQYEEQDDI KETDILSDDD
EFCESLKGAS VDRDLQEQLQ AASISQRARG RRTLDSHASR MTQLKKQAAL SGINGGLESA
SEEVIWVRRE DFAPSRKLNT EI
//
