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Database: UniProt
Entry: Q3XZE6_ENTFC
LinkDB: Q3XZE6_ENTFC
Original site: Q3XZE6_ENTFC 
ID   Q3XZE6_ENTFC            Unreviewed;       444 AA.
AC   Q3XZE6;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   25-OCT-2017, entry version 88.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AFK57625.1};
GN   ORFNames=HMPREF0351_10001 {ECO:0000313|EMBL:AFK57625.1};
OS   Enterococcus faecium DO.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=333849 {ECO:0000313|EMBL:AFK57625.1, ECO:0000313|Proteomes:UP000005269};
RN   [1] {ECO:0000313|EMBL:AFK57625.1, ECO:0000313|Proteomes:UP000005269}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DO {ECO:0000313|EMBL:AFK57625.1,
RC   ECO:0000313|Proteomes:UP000005269};
RX   PubMed=22769602; DOI=10.1186/1471-2180-12-135;
RA   Qin X., Galloway-Pena J.R., Sillanpaa J., Hyeob Roh J.,
RA   Nallapareddy S.R., Chowdhury S., Bourgogne A., Choudhury T.,
RA   Munzy D.M., Buhay C.J., Ding Y., Dugan-Rocha S., Liu W., Kovar C.,
RA   Sodergren E., Highlander S., Petrosino J.F., Worley K.C., Gibbs R.A.,
RA   Weinstock G.M., Murray B.E.;
RT   "Complete genome sequence of Enterococcus faecium strain TX16 and
RT   comparative genomic analysis of Enterococcus faecium genomes.";
RL   BMC Microbiol. 12:135-135(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP003583; AFK57625.1; -; Genomic_DNA.
DR   RefSeq; WP_002288360.1; NZ_AAAK03000035.1.
DR   RefSeq; YP_006374607.1; NC_017960.1.
DR   ProteinModelPortal; Q3XZE6; -.
DR   EnsemblBacteria; AFK57625; AFK57625; HMPREF0351_10001.
DR   GeneID; 13001437; -.
DR   KEGG; efu:HMPREF0351_10001; -.
DR   KO; K02313; -.
DR   Proteomes; UP000005269; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005269};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005269}.
FT   DOMAIN      140    271       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      352    421       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     148    155       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   444 AA;  50006 MW;  57FAA772D0168853 CRC64;
     MVSLDALWNE LKATYQKDLS PASYNTWIET ANPRTLDQNQ LVVEVPSKIH KEYWEKNLAT
     KIVEVGYMLS GNEIIPRFIT GEEAEQEEVI EEKNPKVVAP SPLKKAMLNP KYTFDTFVIG
     KGNQMAHAAA LVVAEDPGSI YNPLFFYGGV GLGKTHLMHA IGHQMLQSQP NAKVKYVSSE
     TFANDFINSI QNKTAEEFRQ EYRNVDLLLV DDIQFFAEKE ATQEEFFHTF NALYNEGKQI
     VLTSDRLPNE IPKLQERLVS RFAWGLSVDI TPPDLETRTA ILRKKAAAER LEIPDDTLSY
     IAGQIDSNIR ELEGALVRVQ AFAAMNSEDI STSLAADALK TLKSGKGHPQ LSILQIQEEV
     AKYYHIQLKD LKGKKRVKSI VVPRQIAMYL ARELTDNSLP KIGAEFGGKD HTTVIHAHEK
     IQQLMDSSVS MQNEVSEIKN FLLN
//
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