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Database: UniProt
Entry: Q3Z8C1
LinkDB: Q3Z8C1
Original site: Q3Z8C1 
ID   QUEA_DEHM1              Reviewed;         343 AA.
AC   Q3Z8C1;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase {ECO:0000255|HAMAP-Rule:MF_00113};
DE            EC=2.4.99.17 {ECO:0000255|HAMAP-Rule:MF_00113};
DE   AltName: Full=Queuosine biosynthesis protein QueA {ECO:0000255|HAMAP-Rule:MF_00113};
GN   Name=queA {ECO:0000255|HAMAP-Rule:MF_00113};
GN   OrderedLocusNames=DET0796;
OS   Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)
OS   (Dehalococcoides ethenogenes (strain 195)).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2266 / KCTC 15142 / 195;
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M.,
RA   Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M.,
RA   Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M.,
RA   Sullivan S.A., Madupu R., Nelson K.E., Kang K.H., Impraim M., Tran K.,
RA   Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H.,
RA   Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- FUNCTION: Transfers and isomerizes the ribose moiety from AdoMet
CC       to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give
CC       epoxyqueuosine (oQ-tRNA). {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 7-aminomethyl-7-
CC       carbaguanosine(34) in tRNA = L-methionine + adenine +
CC       epoxyqueuosine(34) in tRNA. {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00113}.
CC   -!- SIMILARITY: Belongs to the QueA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00113}.
DR   EMBL; CP000027; AAW39891.1; -; Genomic_DNA.
DR   RefSeq; WP_010936529.1; NC_002936.3.
DR   ProteinModelPortal; Q3Z8C1; -.
DR   STRING; 243164.DET0796; -.
DR   EnsemblBacteria; AAW39891; AAW39891; DET0796.
DR   KEGG; det:DET0796; -.
DR   PATRIC; fig|243164.10.peg.760; -.
DR   eggNOG; ENOG4105E2N; Bacteria.
DR   eggNOG; COG0809; LUCA.
DR   HOGENOM; HOG000004402; -.
DR   KO; K07568; -.
DR   OMA; LSKHKMD; -.
DR   OrthoDB; POG091H00ZG; -.
DR   UniPathway; UPA00392; -.
DR   Proteomes; UP000008289; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00113; QueA; 1.
DR   InterPro; IPR003699; QueA.
DR   Pfam; PF02547; Queuosine_synth; 1.
DR   SUPFAM; SSF111337; SSF111337; 1.
DR   TIGRFAMs; TIGR00113; queA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Queuosine biosynthesis;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    343       S-adenosylmethionine:tRNA
FT                                ribosyltransferase-isomerase.
FT                                /FTId=PRO_0000231331.
SQ   SEQUENCE   343 AA;  38221 MW;  6704D10E963C3C5E CRC64;
     MKTSDFDYNL PQEYIAQKPA EPRDSSRLLV LNRQSGELKS CIFRDITGYF QPGDVLVMNN
     SRVLPARIKG IKQDTSAKIE ILLLKSDGNG CWEALLKPGK RTKPGTIIDI RKQDGQIHIQ
     AEVLADKEDG IKLLRFSDET LLMKLGEVPL PPYIHTPVSD PERYQTVYAL TNGSVAAPTA
     GLHFTPELLE RLGDMGVICT YVTLHIGLDT FRPVKEEDPS DHIIHREYGI LSAETAAAIC
     QAKANGKRVF CVGTSATRLV EQASSLSQNG IIELYSGWAD LFILPGYKFK VADCFITNFH
     LPRSTPLMLT AAFAGWPLLQ KAYEKAINEH YRFYSFGDAM LVL
//
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