ID Q3ZI83_DENAT Unreviewed; 177 AA.
AC Q3ZI83;
DT 27-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
DE Flags: Fragment;
OS Dendrobates auratus (Green and black poison dart frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Dendrobatidae; Dendrobatinae;
OC Dendrobates.
OX NCBI_TaxID=43471 {ECO:0000313|EMBL:AAX53906.1};
RN [1] {ECO:0000313|EMBL:AAX53906.1}
RP NUCLEOTIDE SEQUENCE.
RA Faivovich J., Haddad C.F.B., Garcia P.C.A., Frost D.R., Campbell J.A.,
RA Wheeler W.C.;
RT "Systematic Review of the frog family Hylidae, with special reference to
RT the Hylinae: Phylogenetic analysis and taxonomic revision.";
RL Bull. Am. Mus. Nat. Hist. 294:1-240(2005).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SUBCELLULAR LOCATION: Melanosome membrane
CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004573}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY844032; AAX53906.1; -; Genomic_DNA.
DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 144..161
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAX53906.1"
FT NON_TER 177
FT /evidence="ECO:0000313|EMBL:AAX53906.1"
SQ SEQUENCE 177 AA; 20631 MW; 2CD8CA1A94E4DC36 CRC64;
VLSXSPSGSQ FPFSGIDDRE NWPIVFYNRT CQCQGNFMGY NCGDCKFGFI GLNCTVRRTM
IRKEIFRMTV AEKDKFIAYL NFAKRSISSD YVIATGTYEQ MNNGSNPLFA DISVYDLFVW
LHYYASRDAF LEGDLVWRNI DFAHEAPAFL PWHRFFLLHW ENEIQKLTGD ENFTIPX
//