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Database: UniProt
Entry: Q3ZI83_DENAT
LinkDB: Q3ZI83_DENAT
Original site: Q3ZI83_DENAT 
ID   Q3ZI83_DENAT            Unreviewed;       177 AA.
AC   Q3ZI83;
DT   27-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2005, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE   AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
DE   Flags: Fragment;
OS   Dendrobates auratus (Green and black poison dart frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Dendrobatidae; Dendrobatinae;
OC   Dendrobates.
OX   NCBI_TaxID=43471 {ECO:0000313|EMBL:AAX53906.1};
RN   [1] {ECO:0000313|EMBL:AAX53906.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Faivovich J., Haddad C.F.B., Garcia P.C.A., Frost D.R., Campbell J.A.,
RA   Wheeler W.C.;
RT   "Systematic Review of the frog family Hylidae, with special reference to
RT   the Hylinae: Phylogenetic analysis and taxonomic revision.";
RL   Bull. Am. Mus. Nat. Hist. 294:1-240(2005).
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane
CC       {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004573}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
CC       {ECO:0000256|ARBA:ARBA00009928}.
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DR   EMBL; AY844032; AAX53906.1; -; Genomic_DNA.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT   DOMAIN          144..161
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAX53906.1"
FT   NON_TER         177
FT                   /evidence="ECO:0000313|EMBL:AAX53906.1"
SQ   SEQUENCE   177 AA;  20631 MW;  2CD8CA1A94E4DC36 CRC64;
     VLSXSPSGSQ FPFSGIDDRE NWPIVFYNRT CQCQGNFMGY NCGDCKFGFI GLNCTVRRTM
     IRKEIFRMTV AEKDKFIAYL NFAKRSISSD YVIATGTYEQ MNNGSNPLFA DISVYDLFVW
     LHYYASRDAF LEGDLVWRNI DFAHEAPAFL PWHRFFLLHW ENEIQKLTGD ENFTIPX
//
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