ID   Q45IA2_9HIV1            Unreviewed;       210 AA.
AC   Q45IA2;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAZ50144.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AAZ50144.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAZ50144.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAZ50144.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NP259 {ECO:0000313|EMBL:AAZ50144.1};
RA   Chantratita W., Pongthanapisit V., Wathitphun C., Pasomsub E.;
RT   "Prevalence of mutations related to HIV-1 antiretroviral drug resistance in
RT   Thailand, 2003.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ130854; AAZ50144.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:AAZ50144.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          7..197
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAZ50144.1"
FT   NON_TER         210
FT                   /evidence="ECO:0000313|EMBL:AAZ50144.1"
SQ   SEQUENCE   210 AA;  24563 MW;  ADDAED9AB772E5CA CRC64;
     CKEMEEEGKI SKIGPENPYN TPVFAIKKKN STRWRKLVDF RELNKRTQDF WEVQLGIPHP
     AGLKRKKSVT VLDVGDAYFS VPLDESFRKY TAFTIPSINN ETPGIRYQYN VLPQGWKGSP
     AIFQSSMTKI LEPFRIKNPE IVIYQYVDDL YVGSDLEIGQ HRIKIEELRA HLLSWGFTTP
     DQKHQKEPPF LWMGYELHPD RWTVQPIELP
//