ID Q45ZT1_9MICR Unreviewed; 403 AA.
AC Q45ZT1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Tubulin beta chain {ECO:0000256|RuleBase:RU000352};
DE Flags: Fragment;
OS Nosema sp. 'plutellae'.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX NCBI_TaxID=319078 {ECO:0000313|EMBL:AAZ23552.1};
RN [1] {ECO:0000313|EMBL:AAZ23552.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PX2 {ECO:0000313|EMBL:AAZ23552.1};
RA Wang C.-H., Ku C.-T., Tzeng C.-C.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ23552.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PX2 {ECO:0000313|EMBL:AAZ23552.1};
RX PubMed=17266983; DOI=10.1016/j.jip.2006.11.008;
RA Ku C.T., Wang C.Y., Tsai Y.C., Tzeng C.C., Wang C.H.;
RT "Phylogenetic analysis of two putative Nosema isolates from Cruciferous
RT Lepidopteran pests in Taiwan.";
RL J. Invertebr. Pathol. 95:71-76(2007).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC consisting of laterally associated linear protofilaments composed of
CC alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC GTPase activity of alpha-tubulin. {ECO:0000256|RuleBase:RU000352}.
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; DQ083404; AAZ23552.1; -; Genomic_DNA.
DR AlphaFoldDB; Q45ZT1; -.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02187; beta_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002453; Beta_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF429; TUBULIN BETA-1 CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01163; BETATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}.
FT DOMAIN 39..236
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 238..375
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAZ23552.1"
FT NON_TER 403
FT /evidence="ECO:0000313|EMBL:AAZ23552.1"
SQ SEQUENCE 403 AA; 44960 MW; EE5A0170F70D84BE CRC64;
LQDSVNQVGG KFWETISNEH GISPEGKYVG TSDNQLERIN VYYNESSCKK YVPRAVLIDL
EPGTMDAIRQ GPYGELFRPD NFVFGQSGAG NNWAKGHYTE GAELIDSVMD VVRKEAESSD
CLQGFQITHS LGGGTGAGMG TLLISKIREE FSDRMICTFS VVPSPKVSDT VVEPYNATLS
IHQLVENADE TFCIDNEALY DICFKTLKLN NPGYGDLNHL VSLVMSGVTT CLRFPGQLNA
DLRKLAVNMI PFPRLHFFVV SFTPLIAQGT QRFKTYSVSE LTQQMFDSRN MMTACDPKKG
RYLTVAAVFR GKISMKDVDE QMSSIQTKSS NLFVEWIPSN VKTAVCDIAP TGFEMSGTFM
GNTTAIQELF KRISEQFSLM FRKKAFLHWY TGEGMDEMEF SEA
//
