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Database: UniProt
Entry: Q45ZY2_STRPU
LinkDB: Q45ZY2_STRPU
Original site: Q45ZY2_STRPU 
ID   Q45ZY2_STRPU            Unreviewed;       638 AA.
AC   Q45ZY2;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   30-AUG-2017, entry version 89.
DE   SubName: Full=Hyperpolarization-gated and cyclic nucleotide regulated channel {ECO:0000313|EMBL:AAZ03555.1};
DE   SubName: Full=Hyperpolarization-gated and cyclic nucleotide regulated channel; Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SPU_013642-tr};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EMBL:AAZ03555.1};
RN   [1] {ECO:0000313|EMBL:AAZ03555.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Sperm {ECO:0000313|EMBL:AAZ03555.1};
RX   PubMed=15992765; DOI=10.1016/j.bbrc.2005.06.074;
RA   Galindo B.E., Neill A.T., Vacquier V.D.;
RT   "A new hyperpolarization-activated, cyclic nucleotide-gated channel
RT   from sea urchin sperm flagella.";
RL   Biochem. Biophys. Res. Commun. 334:96-101(2005).
RN   [2] {ECO:0000313|EnsemblMetazoa:SPU_013642-tr}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:SPU_013642-tr}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AAGJ04030728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04143745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ079999; AAZ03555.1; -; mRNA.
DR   RefSeq; NP_001028182.1; NM_001033010.1.
DR   UniGene; Spu.15568; -.
DR   STRING; 7668.SPU_013642tr; -.
DR   EnsemblMetazoa; SPU_013642-tr; SPU_013642-tr; SPU_013642.
DR   EnsemblMetazoa; SPU_020643-tr; SPU_020643-tr; SPU_020643.
DR   GeneID; 593273; -.
DR   KEGG; spu:593273; -.
DR   CTD; 610; -.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   OrthoDB; EOG091G0714; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007110};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    131    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    208    226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    354    382       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      457    572       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   638 AA;  73966 MW;  21D99E17F3AFE657 CRC64;
     MSTAMANKVM PDTQGEFVKV KRPDRLSKIS ALRKDFDVKK AAVLKEKPKE RRASLPSAMT
     DKSPGHRDSL VVDLGGAGRR NSMPTKESLF LASGSDFVKK IYRSEKALKD EQERQQNIRR
     FVIHPFSNFR WYWDLFMVFL LLITLVLLPV NVTFFSDDIT MYWIIINCIS DTLFMLDITL
     NFFTGVIENA EDTVTLDRTK IIFSSLRGWF FLDLISSFPF DYIYLFLGQV DFTSHTALAL
     RILRLTKVLS LLRLLRLSRL LRYIHRPEEL LNVETAVIRI VHLVFVMLLL MHWNGCIQFL
     VPFFQTFPPD CWVVINGLEN AGKLEQYSWS FFKAICHMIS IGFGRFPPMN VTEMWMTTFS
     IMLGATFYAL FIGTMSTLLL AVDASGRLYN ERLNQVKEYL RYRKVPMNTQ RRVLSYYEHR
     YQRKYFNEKT ILGEQSHPIR REILQHHFNN FITKVNFLNE ADPDFAYDVI EKLSFEVFLE
     GDVIIKAGSL GGAMYFIEHG TVEVLVDDRI VNRLSDGDHF GEISLLIDER RVASIIAATT
     CDVFCLSRED FHKVLKDYPE MGARMAEIAQ ERLNTIDSSL DTVDEEAGDE EEATANNNNN
     HPAKNDKKVK KNDLATPQNK DHIQKINDWL KENFAQRI
//
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