ID Q46EP4_METBF Unreviewed; 663 AA.
AC Q46EP4;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Kef-type potassium/proton antiporter, CPA2 family {ECO:0000313|EMBL:AAZ69648.1};
GN OrderedLocusNames=Mbar_A0669 {ECO:0000313|EMBL:AAZ69648.1};
OS Methanosarcina barkeri (strain Fusaro / DSM 804).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=269797 {ECO:0000313|EMBL:AAZ69648.1};
RN [1] {ECO:0000313|EMBL:AAZ69648.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fusaro {ECO:0000313|EMBL:AAZ69648.1};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Goodwin L.A., Saunders E.H., Schmutz J.,
RA Larimer F., Land M., Anderson I., Richardson P.;
RT "Complete sequence of chromosome 1 of Methanosarcina barkeri str. fusaro.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; CP000099; AAZ69648.1; -; Genomic_DNA.
DR AlphaFoldDB; Q46EP4; -.
DR STRING; 269797.Mbar_A0669; -.
DR PaxDb; 269797-Mbar_A0669; -.
DR KEGG; mba:Mbar_A0669; -.
DR eggNOG; arCOG01955; Archaea.
DR HOGENOM; CLU_005126_9_0_2; -.
DR OrthoDB; 43518at2157; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 412..534
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 574..660
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 663 AA; 73197 MW; 2C41B1EFFE58FDA8 CRC64;
MTDNLLTDLL IIFGLSIPVV FTFSRLKIAP LIGFLLAGIL AGPFGFGFIR EIENIELLAE
IGVVLLLFTI GIEFSMRDLL QLRRIVIFGG GLQLSITSVI VALILLWLGH SRETSIFLGL
LVALSSTAIV LKLLQEKGEI YSLHGRTSLG ILIFQDIAAV IIILLIPVLA GTPGTEKSFL
ELILQGFGLI VFTFLSARYV VPFIMYHVAK TRNNELFLLS VVVIGLSVAW LTSMVGLSLA
LGAFLAGLII SESEYSVQAL GNLIPFRDMF MSIFFISIGM LLDLNILREH LLLILAATLA
VLFLKVLVNS LSTFLIGFPL NTMILVGFSL SQVGEFSFIV AKVGLASGLI SSLIYQEFLN
VVVLSMVLTP LFMSIGYRTT VFAEFLPLPP VLKRGWYSKF KESGPEEKPE NHVIIVGFGI
NGKNVVTAAK ETSIPYIVID MNPEVVRIEK QREEHIFYGD AAQNAVLEHA GIRTAKSFVV
TAGDPPSAKR IIETARRLNP EIHIIARTHF LRELDKFYDF GADEVISDEF ESSIELFTRV
LHRYLVPSSE IDSLTSTLRA DHYKMLRSPG IPRKKFCDLA LDFADVEIRS IRVGKFSKSA
GMTLGELNLR KNYGVSALAI SRSHRIIPGP EAGTIILADD ILLVISPPKN IDVVRKLFED
SKE
//
