ID Q46GT2_PROMT Unreviewed; 344 AA.
AC Q46GT2;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=CobW C-terminal domain-containing protein {ECO:0000259|SMART:SM00833};
GN OrderedLocusNames=PMN2A_1823 {ECO:0000313|EMBL:AAZ59311.1};
OS Prochlorococcus marinus (strain NATL2A).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=59920 {ECO:0000313|EMBL:AAZ59311.1, ECO:0000313|Proteomes:UP000002535};
RN [1] {ECO:0000313|EMBL:AAZ59311.1, ECO:0000313|Proteomes:UP000002535}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NATL2A {ECO:0000313|EMBL:AAZ59311.1,
RC ECO:0000313|Proteomes:UP000002535};
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP000095; AAZ59311.1; -; Genomic_DNA.
DR RefSeq; WP_011294455.1; NC_007335.2.
DR AlphaFoldDB; Q46GT2; -.
DR STRING; 59920.PMN2A_1823; -.
DR KEGG; pmn:PMN2A_1823; -.
DR HOGENOM; CLU_017452_1_1_3; -.
DR OrthoDB; 517607at2; -.
DR PhylomeDB; Q46GT2; -.
DR Proteomes; UP000002535; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF65; 47 KD PROTEIN; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002535}.
FT DOMAIN 254..342
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
FT REGION 222..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 38657 MW; E0701A9DCA1783A4 CRC64;
MNASVSNLNK NMVSKKNIPI TIISGFLGSG KTTLLNHILT NQQGIKTAVL VNEFGEIGID
NELIIKTEEE MIELSNGCIC CSINGELVEA IEKLINVNKK LDYIIIETTG LADPLPVAMT
LLGSDLRDQT RLDSIITLID AENFNDVALE SSIGRSQVIY GDILLLNKCD LVTNKNIEET
IDKLKEIKND VRILKSIKGN IPLNLLLSVG LFETDLINQK ESVHDHSHEH KHGHGHGHGH
GHGHSEEDNR IEDFLSVSFQ TKEPFSLRKF QYFLDNQLKS DVFRAKGILW FSESERRHVF
HLAGKRISIE DSEWGEERNN QLVFIGKELD KTKILSQLNA CIDK
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