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Database: UniProt
Entry: Q46WL4
LinkDB: Q46WL4
Original site: Q46WL4 
ID   HIS7_CUPPJ              Reviewed;         195 AA.
AC   Q46WL4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   01-OCT-2014, entry version 58.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076};
DE            Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076};
DE            EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076};
GN   Name=hisB {ECO:0000255|HAMAP-Rule:MF_00076};
GN   OrderedLocusNames=Reut_A3109;
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia
OS   eutropha (strain JMP 134)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 / LMG 1197;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M.,
RA   Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-
CC       phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CC       {ECO:0000255|HAMAP-Rule:MF_00076}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC       {ECO:0000255|HAMAP-Rule:MF_00076}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00076}.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000255|HAMAP-Rule:MF_00076}.
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DR   EMBL; CP000090; AAZ62469.1; -; Genomic_DNA.
DR   RefSeq; WP_011299252.1; NC_007347.1.
DR   RefSeq; YP_297313.1; NC_007347.1.
DR   ProteinModelPortal; Q46WL4; -.
DR   SMR; Q46WL4; 2-183.
DR   STRING; 264198.Reut_A3109; -.
DR   EnsemblBacteria; AAZ62469; AAZ62469; Reut_A3109.
DR   GeneID; 3609700; -.
DR   KEGG; reu:Reut_A3109; -.
DR   PATRIC; 20231932; VBIRalEut24049_3792.
DR   eggNOG; COG0131; -.
DR   HOGENOM; HOG000228064; -.
DR   KO; K01693; -.
DR   OMA; HHIAESC; -.
DR   OrthoDB; EOG60PHGP; -.
DR   BioCyc; CPIN264198:GIW3-3163-MONOMER; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133:SF2; PTHR23133:SF2; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Lyase.
FT   CHAIN         1    195       Imidazoleglycerol-phosphate dehydratase.
FT                                /FTId=PRO_1000010339.
SQ   SEQUENCE   195 AA;  21487 MW;  616657E3738C5923 CRC64;
     MRVAEVTRNT SETQIRVSLN LDGTGRQKLA SGVPFLDHML DQIARHGMFD LEVEATGDTH
     IDDHHTVEDV GITLGQAVAK AIGDKKGITR YGHSYVPLDE CLSRVVIDFS GRPGLEFHVP
     FTRARVGSFD VDLTIEFFRG FVNHAGVTLH IDNLRGINAH HQCETVFKAF GRALRMAVEL
     DPRAANTIPS TKGTL
//
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