ID HIS7_CUPPJ Reviewed; 195 AA.
AC Q46WL4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 01-MAY-2013, entry version 50.
DE RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE Short=IGPD;
DE EC=4.2.1.19;
GN Name=hisB; OrderedLocusNames=Reut_A3109;
OS Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes
OS eutrophus) (Ralstonia eutropha).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=264198;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMP134 / LMG 1197;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M.,
RA Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-
CC phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC family.
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DR EMBL; CP000090; AAZ62469.1; -; Genomic_DNA.
DR RefSeq; YP_297313.1; NC_007347.1.
DR HSSP; P34047; 2F1D.
DR ProteinModelPortal; Q46WL4; -.
DR SMR; Q46WL4; 2-183.
DR STRING; 264198.Reut_A3109; -.
DR EnsemblBacteria; AAZ62469; AAZ62469; Reut_A3109.
DR GeneID; 3609700; -.
DR KEGG; reu:Reut_A3109; -.
DR PATRIC; 20231932; VBIRalEut24049_3792.
DR eggNOG; COG0131; -.
DR HOGENOM; HOG000228064; -.
DR KO; K01693; -.
DR OMA; HHIVEAC; -.
DR ProtClustDB; PRK00951; -.
DR BioCyc; CPIN264198:GIW3-3163-MONOMER; -.
DR UniPathway; UPA00031; UER00011.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:HAMAP.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00076; HisB; 1; -.
DR InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR PANTHER; PTHR23133:SF2; PTHR23133:SF2; 1.
DR Pfam; PF00475; IGPD; 1.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 2.
DR PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW Histidine biosynthesis; Lyase.
FT CHAIN 1 195 Imidazoleglycerol-phosphate dehydratase.
FT /FTId=PRO_1000010339.
SQ SEQUENCE 195 AA; 21487 MW; 616657E3738C5923 CRC64;
MRVAEVTRNT SETQIRVSLN LDGTGRQKLA SGVPFLDHML DQIARHGMFD LEVEATGDTH
IDDHHTVEDV GITLGQAVAK AIGDKKGITR YGHSYVPLDE CLSRVVIDFS GRPGLEFHVP
FTRARVGSFD VDLTIEFFRG FVNHAGVTLH IDNLRGINAH HQCETVFKAF GRALRMAVEL
DPRAANTIPS TKGTL
//
