ID OTC_CUPPJ Reviewed; 307 AA.
AC Q46XK9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 01-MAY-2013, entry version 58.
DE RecName: Full=Ornithine carbamoyltransferase;
DE Short=OTCase;
DE EC=2.1.3.3;
GN Name=argF; OrderedLocusNames=Reut_A2763;
OS Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes
OS eutrophus) (Ralstonia eutropha).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=264198;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMP134 / LMG 1197;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M.,
RA Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Reversibly catalyzes the transfer of the carbamoyl group
CC from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine
CC (ORN) to produce L-citrulline (By similarity).
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate
CC + L-citrulline.
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC arginine from L-ornithine and carbamoyl phosphate: step 1/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR EMBL; CP000090; AAZ62124.1; -; Genomic_DNA.
DR RefSeq; YP_296968.1; NC_007347.1.
DR HSSP; P96108; 1VLV.
DR ProteinModelPortal; Q46XK9; -.
DR STRING; 264198.Reut_A2763; -.
DR EnsemblBacteria; AAZ62124; AAZ62124; Reut_A2763.
DR GeneID; 3612333; -.
DR KEGG; reu:Reut_A2763; -.
DR PATRIC; 20231204; VBIRalEut24049_3435.
DR eggNOG; COG0078; -.
DR HOGENOM; HOG000022686; -.
DR OMA; KHLLSIK; -.
DR ProtClustDB; PRK00779; -.
DR BioCyc; CPIN264198:GIW3-2810-MONOMER; -.
DR UniPathway; UPA00068; UER00112.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:HAMAP.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_01109; OTCase; 1; -.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR InterPro; IPR002292; Orn/put_carbamltrans.
DR InterPro; IPR024904; Orn_carbamltrans.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00102; OTCASE.
DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1.
DR TIGRFAMs; TIGR00658; orni_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW Cytoplasm; Transferase.
FT CHAIN 1 307 Ornithine carbamoyltransferase.
FT /FTId=PRO_1000065113.
FT REGION 56 60 Carbamoyl phosphate binding (By
FT similarity).
FT REGION 134 137 Carbamoyl phosphate binding (By
FT similarity).
FT REGION 227 228 Ornithine binding (By similarity).
FT REGION 262 265 Carbamoyl phosphate binding (By
FT similarity).
FT BINDING 10 10 Carbamoyl phosphate (By similarity).
FT BINDING 83 83 Carbamoyl phosphate (By similarity).
FT BINDING 107 107 Carbamoyl phosphate (By similarity).
FT BINDING 165 165 Ornithine (By similarity).
FT BINDING 223 223 Ornithine (By similarity).
FT BINDING 291 291 Carbamoyl phosphate (By similarity).
FT SITE 31 31 Important for structural integrity (By
FT similarity).
FT SITE 147 147 Important for structural integrity (By
FT similarity).
SQ SEQUENCE 307 AA; 34728 MW; 2ACD07F864BCB828 CRC64;
MSSTPIKHYL QFSDLTPDEY EYLLDRARIL KAKFKNYETW HPLHDRTLAM IFEKNSTRTR
LSFEAGIHQL GGHAVFLNTR DSQLGRGEPI EDAAQVISRM VDIIMIRTFG QDIIERFAAH
SRVPVINGLT NEYHPCQVLA DVFTYIEQRG SIRGKTVAWI GDANNMAYTW IQAAERLGFT
FHFSAPPGYQ LDPALVPASA AGQLKVFEDP LAACKGASLV TTDVWTSMGF EAENEARKRA
FQNWMVTTAM MDRAEPDALF MHCLPAHRGE EVEAAVIDGP KSVVWDEAEN RLHVQKALME
YLLCGRY
//
