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Database: UniProt
Entry: Q474V6
LinkDB: Q474V6
Original site: Q474V6 
ID   ARLY_CUPPJ              Reviewed;         470 AA.
AC   Q474V6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   29-OCT-2014, entry version 68.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006};
GN   OrderedLocusNames=Reut_A0695;
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia
OS   eutropha (strain JMP 134)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 / LMG 1197;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M.,
RA   Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2-(N(omega)-L-arginino)succinate = fumarate +
CC       L-arginine. {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC       arginine from L-ornithine and carbamoyl phosphate: step 3/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; CP000090; AAZ60077.1; -; Genomic_DNA.
DR   RefSeq; YP_294921.1; NC_007347.1.
DR   ProteinModelPortal; Q474V6; -.
DR   STRING; 264198.Reut_A0695; -.
DR   EnsemblBacteria; AAZ60077; AAZ60077; Reut_A0695.
DR   GeneID; 3610394; -.
DR   KEGG; reu:Reut_A0695; -.
DR   PATRIC; 20226851; VBIRalEut24049_1301.
DR   eggNOG; COG0165; -.
DR   HOGENOM; HOG000242744; -.
DR   KO; K01755; -.
DR   OMA; KEGIFDA; -.
DR   OrthoDB; EOG6P5ZF8; -.
DR   BioCyc; CPIN264198:GIW3-699-MONOMER; -.
DR   UniPathway; UPA00068; UER00114.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR11444; PTHR11444; 1.
DR   PANTHER; PTHR11444:SF3; PTHR11444:SF3; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW   Cytoplasm; Lyase.
FT   CHAIN         1    470       Argininosuccinate lyase.
FT                                /FTId=PRO_0000240758.
SQ   SEQUENCE   470 AA;  51086 MW;  D583B8D8F88181B8 CRC64;
     MTTSQLAKKG EAWSARFSEP MSDLVKRYTA SVFFDKRLAL FDIQGSLAHA AMLAKQGIIA
     EADRAEIERG MAQIKGEIEA GGFEWKLDLE DVHLNIEARL TALVGDAGKR LHTGRSRNDQ
     VATDIRLWLR SEIDNIIALL GALRGSLLDL ADQNADTILP GFTHLQVAQP VTFGHHLLAY
     VEMFTRDAER MADCRKRVNR LPLGAAALAG TSYPIDREFV AQQLGFDGVC RNSLDAVSDR
     DFAIEFCAAA ALVMTHVSRF SEELVLWMSP RVGFIDIADR FCTGSSIMPQ KKNPDVPELA
     RGKTGRVNGH LIGLLTLMKG QPLAYNKDNQ EDKEPLFDTV DTVVDTLRIF ADMVPGITVK
     PEAMRAAALQ GYATATDLAD YLVKKGLPFR DAHEAVAHAV RACDSRNCDL ADLTVAELRE
     VSGLGDKSAL IGDDVHTVLT LEGSVAARNH IGGTAPDQVR AAIAAARAAL
//
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