ID   Q47RY5_THEFY            Unreviewed;       496 AA.
AC   Q47RY5;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=Aldehyde dehydrogenase (NAD+) {ECO:0000313|EMBL:AAZ54782.1};
GN   OrderedLocusNames=Tfu_0744 {ECO:0000313|EMBL:AAZ54782.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54782.1};
RN   [1] {ECO:0000313|EMBL:AAZ54782.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=YX {ECO:0000313|EMBL:AAZ54782.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA   Larimer F., Land M., Lykidis A., Richardson P.;
RT   "Complete sequence of Thermobifida fusca YX.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP000088; AAZ54782.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q47RY5; -.
DR   STRING; 269800.Tfu_0744; -.
DR   KEGG; tfu:Tfu_0744; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_11; -.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR42991; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42991:SF1; ALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          40..486
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        269
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   496 AA;  52389 MW;  E3526342B191FCEB CRC64;
     MKACVVGPEW MRKTTLRSSS VTNMSQRPFW LAGSATTGDN ELTVTNPYTG QTVATVAVPS
     PEQVDQAVAA AHGALDATAA LPAHVRATAL AHVARRLQER SEEIAQLITA ESGKPILWAR
     AEVGRAVSVF TWAAEEVRRD SGRVQRLDTD SAGEGRIALI RRVPKGAVLA ISPFNFPLNL
     VAHKVAPAIA VGAPIVVKPA PATPLSALVL GEILAETDLP AGAFSVLPMP NELAQPLITD
     ERLPVISFTG GQFGWELRKM APNKHVTLEL GGNAAAVVLA DADLDWAARR IALFGNNQAG
     QVCIGVQRVI VEDAVYDEFA AKLVQRVEEL VTGDPADEAT QVGPLINEAA AARVEQWVNE
     AVAGGATVLT GGTRDGVTMA PTVLADVPDD AKVVCEEVFG PVMVLRRVSG VDEAFAEVNN
     SKYGLQAGVF TRDLATAFRA HRELKVGGVI IGDVPTYRAD QMPYGGVKKS GVGKEGVRSA
     MDDLTDERVM VLTGVL
//