ID Q48RQ0_STRPM Unreviewed; 184 AA.
AC Q48RQ0;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Pyrazinamidase {ECO:0000313|EMBL:AAX72610.2};
DE EC=3.5.1.- {ECO:0000313|EMBL:AAX72610.2};
DE EC=3.5.1.19 {ECO:0000313|EMBL:AAX72610.2};
GN OrderedLocusNames=M28_Spy1500 {ECO:0000313|EMBL:AAX72610.2};
OS Streptococcus pyogenes serotype M28 (strain MGAS6180).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=319701 {ECO:0000313|EMBL:AAX72610.2, ECO:0000313|Proteomes:UP000009292};
RN [1] {ECO:0000313|EMBL:AAX72610.2, ECO:0000313|Proteomes:UP000009292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS6180 {ECO:0000313|EMBL:AAX72610.2,
RC ECO:0000313|Proteomes:UP000009292};
RX PubMed=16088825; DOI=10.1086/430618;
RA Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B.,
RA LeFebvre R.B., Musser J.M.;
RT "Genome sequence of a serotype M28 strain of group A Streptococcus:
RT potential new insights into puerperal sepsis and bacterial disease
RT specificity.";
RL J. Infect. Dis. 192:760-770(2005).
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
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DR EMBL; CP000056; AAX72610.2; -; Genomic_DNA.
DR RefSeq; WP_002988559.1; NC_007296.2.
DR AlphaFoldDB; Q48RQ0; -.
DR GeneID; 69900382; -.
DR KEGG; spb:M28_Spy1500; -.
DR HOGENOM; CLU_068979_12_1_9; -.
DR Proteomes; UP000009292; Chromosome.
DR GO; GO:0008936; F:nicotinamidase activity; IEA:UniProtKB-EC.
DR CDD; cd00431; cysteine_hydrolases; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR PANTHER; PTHR43540:SF10; ISOCHORISMATASE; 1.
DR PANTHER; PTHR43540; PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAX72610.2}.
FT DOMAIN 3..176
FT /note="Isochorismatase-like"
FT /evidence="ECO:0000259|Pfam:PF00857"
SQ SEQUENCE 184 AA; 20754 MW; 8B306FED8BFEC9A2 CRC64;
MRALISIDYT NDFVADDGKL SAGKSAQAIA TKIAEVTKTA FDQGDYIFFA IDCHDQNDPW
HPESKLFAAH NIKGTTGRHL YGPLAEVYSY MKQHPRVFWI DKRYYSAFSG TDLDIRLRER
GITQLVLTGV LSDICVLHTA IDAYHLGYQL EIVKSAVASL TKESYEWSLA HFEQVLGAKL
INDY
//
