ID Q494M1_DROME Unreviewed; 974 AA.
AC Q494M1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 01-MAY-2013, entry version 69.
DE SubName: Full=RE58921p;
DE SubName: Full=Topoisomerase 1, isoform C;
DE EC=5.99.1.-;
DE EC=5.99.1.2;
DE EC=5.99.1.3;
GN Name=Top1; ORFNames=Dmel_CG6146;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE014298; AAX52496.1; -; Genomic_DNA.
DR EMBL; BT023755; AAZ41763.1; -; mRNA.
DR RefSeq; NP_001014742.1; NM_001014742.1.
DR RefSeq; NP_511161.2; NM_078606.3.
DR UniGene; Dm.2912; -.
DR SMR; Q494M1; 428-974.
DR EnsemblMetazoa; FBtr0074005; FBpp0073822; FBgn0004924.
DR EnsemblMetazoa; FBtr0100294; FBpp0099689; FBgn0004924.
DR GeneID; 32458; -.
DR KEGG; dme:Dmel_CG6146; -.
DR UCSC; CG6146-RC; d. melanogaster.
DR CTD; 7150; -.
DR FlyBase; FBgn0004924; Top1.
DR GeneTree; ENSGT00390000016347; -.
DR KO; K03163; -.
DR OMA; QGQVKYI; -.
DR ChiTaRS; TOP1; drosophila.
DR GenomeRNAi; 32458; -.
DR NextBio; 778562; -.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
DR GO; GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.10.41; -; 1.
DR Gene3D; 1.10.132.10; -; 1.
DR Gene3D; 2.170.11.10; -; 2.
DR Gene3D; 3.90.15.10; -; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013034; DNA_topo_domain1.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR018521; TopoI_AS.
DR InterPro; IPR025834; TopoI_C_dom.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR014727; TopoI_cat_a/b-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR InterPro; IPR008336; TopoI_DNA-bd_euk.
DR InterPro; IPR013030; TopoI_DNA-bd_mixed-a/b_euk.
DR InterPro; IPR013499; TopoI_euk.
DR InterPro; IPR009054; TopoI_insert_euk.
DR Pfam; PF14370; Topo_C_assoc; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR Pfam; PF02919; Topoisom_I_N; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SMART; SM00435; TOPEUc; 1.
DR SUPFAM; SSF56349; DNA_brk_join_enz; 1.
DR SUPFAM; SSF46596; Topismrse_insert; 1.
DR SUPFAM; SSF56741; TopoI_DNA_bd_euk; 1.
DR PROSITE; PS00176; TOPOISOMERASE_I_EUK; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Isomerase; Reference proteome.
SQ SEQUENCE 974 AA; 111903 MW; 71E599BDCB136C90 CRC64;
MSGDVAAENS IHIQNGGSCE VVQSNGVTTN GHGHHHHHHH SSSSSSSSKH KSSSKDKHRD
REREHKSSNS SSSSKEHKSS SRDKDRHKSS SSSSKHRDKD KERDGSSNSH RSGSSSSHKD
KDGSSSSKHK SSSGHHKRSS KDKERRDKDK DRGSSSSSRH KSSSSSRDKE RSSSSHKSSS
SSSSSKSKHS SSRHSSSSSS KDQPSYDGVF VKPEPVSQQL MHSGSVDAFQ MQQLGSYEAA
AAGTNFNGNG NVAGANYKNG YEESIVDIKK EEESFNNLSQ ASSCDYSMSQ FRADEPPFVV
KHEQSYAEED STMNYNDHDD DADEMNDDEE DVPLAMRKRK QEATDRPDGG MDNDDDDDIP
LLARKKVKKE KIKKESKEKS KKRVKEEPSD DYGNVKPKKK KMKKEPEPAV SPGKRQKAKA
KVEEEEVWRW WEEEKRADGV KWSTLEHKGP VFAPRYERVP RNVRFYYDGK PLELSEETEE
AATFYAKMLN HDYCTKEVFN NNFFKDFRKS MTPREREIIK DFRKCNFQEM FNYFQAESEK
RKAASKEEKL IKKNENEALM KEFGFCMIDG HKEKIGNFRL EPPGLFRGRG EHPKMGMIKR
RIQASDVSIN CGKDSKVPSP PPGSRWKEVR HDNTVTWLAS WIENVQGQVK YIMLNPSSKL
KGEKDHIKYE TARRLDKVID KIRATYRDEW KSKEMRVRQR AVALYFIDKL ALRAGNEKDE
DQADTVGCCS LRVEHVQLHK ELNGKENVVV FDFPGKDSIR YYNEVEVEKR VFKNLELFME
HKKEGDDLFD RLNTQVLNEH LKELMEGLTA KVFRTYNASK TLQSQLDLLT DPSATVPEKL
LAYNRANRAV AILCNHQRSV PKSHEKSMEN LKEKIKAKRE AIEKCESEYH SRDEKKGKQL
ERLRDQLKKL ELQETDRDEN KTIALGTSKL NYLDPRISVA WCKKHDVPIE KIFNKTQRTK
FLWAVHMADE NYRF
//
