ID Q498E8_XENLA Unreviewed; 858 AA.
AC Q498E8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Cullin 4B S homeolog {ECO:0000313|RefSeq:NP_001090088.1};
DE SubName: Full=MGC115611 protein {ECO:0000313|EMBL:AAI00245.1};
GN Name=cul4b.S {ECO:0000313|RefSeq:NP_001090088.1,
GN ECO:0000313|Xenbase:XB-GENE-963634};
GN Synonyms=cul4b {ECO:0000313|RefSeq:NP_001090088.1,
GN ECO:0000313|Xenbase:XB-GENE-963634}, MGC115611
GN {ECO:0000313|EMBL:AAI00245.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI00245.1};
RN [1] {ECO:0000313|RefSeq:NP_001090088.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI00245.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte {ECO:0000313|EMBL:AAI00245.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001090088.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; BC100244; AAI00245.1; -; mRNA.
DR RefSeq; NP_001090088.1; NM_001096619.1.
DR DNASU; 735163; -.
DR GeneID; 735163; -.
DR KEGG; xla:735163; -.
DR AGR; Xenbase:XB-GENE-963634; -.
DR CTD; 735163; -.
DR Xenbase; XB-GENE-963634; cul4b.S.
DR OrthoDB; 21270at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 735163; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF66; CULLIN-4B; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 503..731
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 99075 MW; EF9BBDAB0C643B62 CRC64;
MKDLVASPSG QSKQGLSSPN PPAQEVRTEG NSTSKKRRLN ISSSDKDDLD PLSPARNSSS
SSNHIQKKLR FEDTLDFLGL DVKMTEESSS SSSCSFSSTP QAVRSKNLLI SPVGVGHHAN
GLTKASPVSS FANSKPGSAK KLVIKNFKDK PKLPENYTDE TWQKLKGTVE AIQNSTSIKY
NLEELYQAVE NLCSYKISAN LYKQLRQICE DHIKAQIHQF REDSLDSVLF LKKIDKCWKD
HCRQMIMIRS IFLFLDRTYV LQNSMLPSIW DMGLELFRTH IISDQKVQNK TIDGILLLIE
RERNGEAIDR SLLRSLLSML SDLQIYQDSF EQRFLEETNR LYSAEGQRLM QEREVPEYLH
HVNKRLEEEA DRVITYLDQS TQKPLIATVE KQLLGEHLTA TLQKGLNHLL DENRIQDLSL
LYQLFSRVRG GVQVLLQHWI EYIKAFGSTI VINPEKDKTM VQELLDFKDK VDHVIDVCFL
KNEKFVNAMK EAFETFINKR PNKPAELIAK HVDSKLRTGN KEATDEELEK MLDKIMIIFR
FIYGKDVFEA FYKKDLAKRL LVGKSASVDA EKSMLSKLKH ECGAAFTSKL EGMFKDMELS
KDIMVHFKQY MQNQNVPGNI ELTVNILTMG YWPTYVPMEV LLPPEMVKLQ EIFKTFYLGK
HSGRKLQWQS TLGQCVLKAE FNEGRKELQV SLFQTLVLLM FNEGDEFSLE EIRQATGIED
SELRRTLQSL ACGRARVLVK NPKSKDVDDG DKFTFNDDFR HQLFRIRINQ IQMKETVEEQ
ASTTERVFQD RQYQIDAAIV RIMKMRKTLT HNLLVSEVYN QLKFPVKPAD LKKRIESLID
RDYMERDKEN PNQYNYVA
//
