ID Q49BD1_STRHY Unreviewed; 354 AA.
AC Q49BD1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=HbmO {ECO:0000313|EMBL:AAY28235.1};
GN Name=hbmO {ECO:0000313|EMBL:AAY28235.1};
OS Streptomyces hygroscopicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX NCBI_TaxID=1912 {ECO:0000313|EMBL:AAY28235.1};
RN [1] {ECO:0000313|EMBL:AAY28235.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AM 3672 {ECO:0000313|EMBL:AAY28235.1};
RX PubMed=16085885; DOI=10.1128/AEM.71.8.4862-4871.2005;
RA Rascher A., Hu Z., Buchanan G.O., Reid R., Hutchinson C.R.;
RT "Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin
RT and herbimycin, obtained by gene sequencing and disruption.";
RL Appl. Environ. Microbiol. 71:4862-4871(2005).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; AY947889; AAY28235.1; -; Genomic_DNA.
DR AlphaFoldDB; Q49BD1; -.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd08195; DHQS; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR030960; DHQS/DOIS.
DR PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR43622:SF7; 3-DEHYDROQUINATE SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF01761; DHQ_synthase; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 75..316
FT /note="3-dehydroquinate synthase"
FT /evidence="ECO:0000259|Pfam:PF01761"
SQ SEQUENCE 354 AA; 36776 MW; D65193D8988BE694 CRC64;
MTTSTSTSAT GSASPARQVT VGLAERSYTV HIGHGVQRLL PQVVAALGAR RAVVVTARPA
GQTPDPGVPS LVVPARDGEE AKDLAAVTDL CRRFVGFGLT RSDVVVSCGG GTTTDTVGLA
AALYHRGTPV VHVPTSLLAQ VDASVGGKTA VNLPEGKNLV GAYWQPAAVL CDLEHLKTLP
DREWRNGLGE IARCHFIGAP DLDGLPLLDQ ISASVTLKAG IVAADERDSG LRHLLNYGHT
LGHALERATG FALRHGEGVA IGTVFAGRLA GALGRIGPER VAEHHDVVSR YGLPTGLPPD
VSVSELVELM RLDKKATDGL TFVLDGPEGP GLVRGIPEDT VSTTLAAMPR APAW
//
