ID   Q49IH3_9CLOS            Unreviewed;      2936 AA.
AC   Q49IH3;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   22-FEB-2023, entry version 71.
DE   SubName: Full=Polyprotein {ECO:0000313|EMBL:AAX31603.1};
GN   Name=ORF1a {ECO:0000313|EMBL:AAX31603.1};
OS   Grapevine leafroll-associated virus 2.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Closteroviridae; Closterovirus.
OX   NCBI_TaxID=64003 {ECO:0000313|EMBL:AAX31603.1, ECO:0000313|Proteomes:UP000202455};
RN   [1] {ECO:0000313|Proteomes:UP000202455}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15965606; DOI=10.1007/s11262-004-2197-0;
RA   Meng B., Li C., Goszczynski D., Gonsalves D.;
RT   "Genome sequences and structures of two biologically distinct strains of
RT   Grapevine leafroll-associated virus 2 and sequence analysis.";
RL   Virus Genes 31:31-41(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY881628; AAX31603.1; -; Genomic_RNA.
DR   RefSeq; YP_337911.1; NC_007448.1.
DR   MEROPS; C42.004; -.
DR   GeneID; 3707778; -.
DR   KEGG; vg:3707778; -.
DR   Proteomes; UP000202455; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   InterPro; IPR002588; Alphavirus-like_MT_dom.
DR   InterPro; IPR022054; DUF3614.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008749; Peptidase_C42.
DR   Pfam; PF12267; DUF3614; 1.
DR   Pfam; PF05533; Peptidase_C42; 2.
DR   Pfam; PF01443; Viral_helicase1; 1.
DR   Pfam; PF01660; Vmethyltransf; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000202455}.
FT   DOMAIN          932..1119
FT                   /note="Alphavirus-like MT"
FT                   /evidence="ECO:0000259|PROSITE:PS51743"
FT   DOMAIN          2514..2854
FT                   /note="(+)RNA virus helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51657"
SQ   SEQUENCE   2936 AA;  327116 MW;  4879A8AF121EEBCC CRC64;
     MSSLAISTLP CSVAQLSFGQ PVAAVAKSFL MTSLPSLQTY PSLSELTSFS FCFGVFQNLK
     MFMSFLRSVH VFASFSELST FGSCYEFIRL GGGAHPLFFC SFQCGPLSVS LGLVNGVFAV
     LNLSFPFLSN ASLLMDVGKD VVQVKRKISK LEKKQKKRVF SMARAAARYV PSPRNPKEKR
     AVHVQPLPSG SFRFSQDKNK TELIILSKEA GLVARVKCSA CVVRRRGYGG AVKSVALIAL
     SPFGVKFRCF APSCSTSACL KLRIVRRVAV GDCRGEKVIA ARRAELQKQN FNSRTPKKVR
     ENPAGALEAN SEASATSRVI FFGSFTQPFA LYPHQESAKA NMQHPPVSVV TVERAVAKVA
     PERSVVDKVP TSVGVSPQRG VFSPPTVVRN CGDIVVTGVV HEALKKIKDG LLRFRIGGDM
     RFSRFFSSNY GCRFVANVRT NTTVWLNCTK ASGEKFSLAV ACSVDYVAML RYVCGGKFPL
     VLMSRINYQD GHCYLAHMRY LCAFYCRPFR ESDYALGSWP TVARLKACVE KNFGVEACGI
     ALRGYYTSRN VYHCDYDSSY MRGFRNLSGR VGGGSFDPSS LTSVITVKTS GLPDSRPKSI
     VFGAFRCDIR YIEPADSGGV QSSAKMKREE VRRVVKKCAA GEAAAQSRRK KIEEKYRDGI
     PDGGFPHLLA GNLNEVRRKV AAGVLRFRVG GDMDFHRSFT THSGYHLLVW RRSSRSVCIE
     LYSPSKAFLR YDFLPCSVDY AAMFSFAAGG RFPLVLMTRI KYLNGFCYLA HCRYACAFLL
     KGFDPKRFDI GAFPTAADLR RRMVSVLGDR SLGLNLYGAY TSRGVFHCDY DAKYIKDLRR
     MSAVIAGKDG VEEVVPSDIT PAMKQKTIEA VYDRLYGGTD SLLKLSIEKD LIDFKNDVQS
     LKKDRPIVKV PFYMSEATQN SLTRFYPQFE LKFSHSSHSD HPAAAASRLL ENETLVRLCG
     NSVSDIGGCP LFHLNSKTQR RVHVCRPVLD GKDAQRRVVR DLQYSNVRSG DDDKILEGPR
     NVDVCHYPLG ACDRESSAMM MVQVYDASLY EICGAMIKKK SHITYLTMVT PGEFLDGREC
     VYMESLDCEI EVDVHADVVM YKFGSSCYSH KLSVIKDIMT TPYLMLGGFL FSVEMYEVRM
     GVNYFKITKS EVSPSVSCTK LLRYRRANSD VVKVKLPRFD KKRRMCLPGY DTIYLDSKFV
     SRVFDYVVCN CSAVNSKTFE WVWSFIKSSK SRVIISGKII HKDVNLDLKY VESFAAVMLA
     SGVRSRLASE YLAKNLSHFS GDCSFIEATS FVLREKIRNM TLNFNERLLQ LVKRVAFATL
     DVSFLDLDST LESITDFAEC KVAVELDELG CLRAEAENEK IRNLAGDSIA AKLASEIVVD
     IDSKPPLRQM SNSSSENVDK REIQRPGLRG GSRIGVVGEF LHFVVSSALR IFKYATDQQR
     IKSYVRFLDS AVSFLDYNYE NLSFIMQVLS KGYSCMFTFF ANRGDVSSRI RSAVCAVKEV
     AASCASASVS KAKVMITFAA AVCAMMFNSC GFSGDGREYK SYVHRYTQVL FDTIFFEDSS
     YLPIEVLSSA ICGAIVTLFS SGASVSLNAF LLQITKGFSL EVVVRNVVRV THGLSTTATD
     GVIRGVFSQI MSHLLVGSTG NVAYQLAFIA GVVPLLVKKC VSLIFIMRED TYSGFIKHGI
     SEFSFLSSVL TFLKGKLVDE LKSVIQGVFE SNKHVFKEAT QEAIRTTVMQ VPVAVVDALK
     CAAGRVYNSF ASRRTFGKDN GSSSEDACEE YFSCDEGDGP GLKGGSSYGF SVLAFFSRII
     WGARRFIAKM KHECFGKLFD FLSLRLHEFR TRVFGKNRAD VGVYDFLPTD IVETLSSIEE
     CDQIEELLGD DLNGVKDDSL TDMSYFEFSE DFLASVEEPP FAGLRGGSKN VTILAILEYV
     YNLFRIVANK CSKGPLLVAF AELSSALIER FKGKFSRKNK IFTIVREYAL SSLRCRMRAL
     GLNNDFVVNS FADLLPMLVK RKVSNSFLSS VYRPIKSFSY MCASAERREK FLALVCLVGL
     SLPFFVRIVG AKACEELVSS ARRFCERVKV FLKQKCVSLL SFLSCLFFSD AGDSSASAGL
     RGGASRVTLF HLFVRLASAL LSLGWEGLKL LLSHHNLLFL CFAMVDDVNV FVKALGGLSF
     FVQPVSSVFA AVLLQPDRFA GYSEKLVTAF EFILKCSPRA PALLKTFFEG VANSTVSKTV
     RKLLRFLVRK FKLRKRGGLR ADGKGFHRQK AVPVIPSNRI TTDGVERLSV KMQGVEALRT
     ELRVLEDLDS AVIEKLNRRR NRDTSDDEFT RPAYEQIQEV TTFCSKANSA GLALERAVLV
     EDAVKSEKLS KTIDEMARKG ATTSDEVAVA LSDDEAVEEI SVAEERDDSP KTVRMSEYLN
     RLNSSFEFPK PIIVDDNKDT GGLTNAVREF YYMQELALFE IHSKLCTYYD QLRIVNFDRS
     VAPCSEDAQL YVRKSGSTIV QGKEARLHIK DFHDHDFLFD GRISINKRRR GGNVLYHDNL
     AFLASNLFLA GYPFSRSFVF TNSSVDILLY EAPPGGGKTT TLIDSFLKVF KKGEVSTMIL
     TANKSSQVEI LKKVEKEVSN IECQKRKDKR SPKKSIYTID AYLMHHRGCD ADVLFIDECF
     MVHAGSVLAC IEFTRCHKVM IFGDSRQIHY IERNDLDKCL YGDLDRFVDL QCRVYGNVSY
     RCPWDVCAWL STVYGNLIAT VKGESEGKSS MRINEINSVD DLVPDMGSTY LCMLQSEKLE
     ISKHFIRKGL TKLNVLTVHE AQGETYARVN LVRLKFQEDE PFKSIRHITV ALSRHTDSLT
     YSVLAARRGD ATCDAIQKAA ELVNKFRVFP TSFGGSVINL NVKKDVEDNS RCKASSAPLS
     VINDFLNEVN PGTAVIDFGD LSADFSTGPF ECGASGIVVR DNISSSSITD HDKQRV
//