ID   Q49WY0_STAS1            Unreviewed;       435 AA.
AC   Q49WY0;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Uracil permease {ECO:0000313|EMBL:BAE18718.1};
GN   OrderedLocusNames=SSP1573 {ECO:0000313|EMBL:BAE18718.1};
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451 {ECO:0000313|EMBL:BAE18718.1, ECO:0000313|Proteomes:UP000006371};
RN   [1] {ECO:0000313|EMBL:BAE18718.1, ECO:0000313|Proteomes:UP000006371}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41
RC   {ECO:0000313|Proteomes:UP000006371};
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; AP008934; BAE18718.1; -; Genomic_DNA.
DR   RefSeq; WP_002483529.1; NZ_MTGA01000034.1.
DR   AlphaFoldDB; Q49WY0; -.
DR   DNASU; 3615317; -.
DR   GeneID; 66867786; -.
DR   KEGG; ssp:SSP1573; -.
DR   PATRIC; fig|342451.11.peg.1575; -.
DR   eggNOG; COG2233; Bacteria.
DR   HOGENOM; CLU_017959_1_2_9; -.
DR   OrthoDB; 9779092at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006371};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        52..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        318..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        349..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   435 AA;  46222 MW;  E3E0ECBDC9DAC482 CRC64;
     MENETMFERT VKPVLDVQDK PKIGQWAFLS TQHLFAMFGS TVLVPFLTGL PISSALLASG
     IGTLLYILIT KAKIPAYLGS SFAFITPIIT GLNSHSLGDM LMALFMSGVM YVLIGLAIRL
     SGTGWLMHLL PPVVVGPVIM VIGLSLAPTA VNMAMFENSG DMKGYNLSYL IVAMITLLVT
     IIVQGYFKGF LSLIPVLIGI ITGYIVSACM GLVNFAPIAK AKWLQFPEVY IPFKDYTPSF
     HLGLILVLIP IVFVTVSEHI GHQMVINKIV GRNFFKDPGL DKSIIGDGVS TMFASIIGGP
     PSTTYGENIG VLAITKIYSV YVIGGAAVIA IILGFVGKFT ALVSSIPTPV MGGVSILLFG
     IIAASGLRML VESEVDFASN RNLVIASVIL VIGIGNLVFN LNGLGINLEI EGMALAALAG
     IILNLILPKT APTNN
//