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Database: UniProt
Entry: Q4A589
LinkDB: Q4A589
Original site: Q4A589 
ID   RNC_MYCS5               Reviewed;         231 AA.
AC   Q4A589;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   01-OCT-2014, entry version 57.
DE   RecName: Full=Ribonuclease 3 {ECO:0000255|HAMAP-Rule:MF_00104};
DE            EC=3.1.26.3 {ECO:0000255|HAMAP-Rule:MF_00104};
DE   AltName: Full=Ribonuclease III {ECO:0000255|HAMAP-Rule:MF_00104};
DE            Short=RNase III {ECO:0000255|HAMAP-Rule:MF_00104};
GN   Name=rnc {ECO:0000255|HAMAP-Rule:MF_00104};
GN   OrderedLocusNames=MS53_0675;
OS   Mycoplasma synoviae (strain 53).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=262723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=53;
RX   PubMed=16077101; DOI=10.1128/JB.187.16.5568-5577.2005;
RA   Vasconcelos A.T.R., Ferreira H.B., Bizarro C.V., Bonatto S.L.,
RA   Carvalho M.O., Pinto P.M., Almeida D.F., Almeida L.G.P., Almeida R.,
RA   Alves-Junior L., Assuncao E.N., Azevedo V.A.C., Bogo M.R.,
RA   Brigido M.M., Brocchi M., Burity H.A., Camargo A.A., Camargo S.S.,
RA   Carepo M.S., Carraro D.M., de Mattos Cascardo J.C., Castro L.A.,
RA   Cavalcanti G., Chemale G., Collevatti R.G., Cunha C.W.,
RA   Dallagiovanna B., Dambros B.P., Dellagostin O.A., Falcao C.,
RA   Fantinatti-Garboggini F., Felipe M.S.S., Fiorentin L., Franco G.R.,
RA   Freitas N.S.A., Frias D., Grangeiro T.B., Grisard E.C.,
RA   Guimaraes C.T., Hungria M., Jardim S.N., Krieger M.A., Laurino J.P.,
RA   Lima L.F.A., Lopes M.I., Loreto E.L.S., Madeira H.M.F., Manfio G.P.,
RA   Maranhao A.Q., Martinkovics C.T., Medeiros S.R.B., Moreira M.A.M.,
RA   Neiva M., Ramalho-Neto C.E., Nicolas M.F., Oliveira S.C.,
RA   Paixao R.F.C., Pedrosa F.O., Pena S.D.J., Pereira M.,
RA   Pereira-Ferrari L., Piffer I., Pinto L.S., Potrich D.P., Salim A.C.M.,
RA   Santos F.R., Schmitt R., Schneider M.P.C., Schrank A., Schrank I.S.,
RA   Schuck A.F., Seuanez H.N., Silva D.W., Silva R., Silva S.C.,
RA   Soares C.M.A., Souza K.R.L., Souza R.C., Staats C.C., Steffens M.B.R.,
RA   Teixeira S.M.R., Urmenyi T.P., Vainstein M.H., Zuccherato L.W.,
RA   Simpson A.J.G., Zaha A.;
RT   "Swine and poultry pathogens: the complete genome sequences of two
RT   strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma
RT   synoviae.";
RL   J. Bacteriol. 187:5568-5577(2005).
CC   -!- FUNCTION: Digests double-stranded RNA. Involved in the processing
CC       of primary rRNA transcript to yield the immediate precursors to
CC       the large and small rRNAs (23S and 16S). Processes some mRNAs, and
CC       tRNAs when they are encoded in the rRNA operon. Processes pre-
CC       crRNA and tracrRNA of type II CRISPR loci if present in the
CC       organism. {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC       phosphomonoester. {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- COFACTOR: Mg(2+). {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SIMILARITY: Contains 1 RNase III domain. {ECO:0000255|HAMAP-
CC       Rule:MF_00104}.
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DR   EMBL; AE017245; AAZ44082.1; -; Genomic_DNA.
DR   RefSeq; WP_011283811.1; NC_007294.1.
DR   RefSeq; YP_278793.1; NC_007294.1.
DR   ProteinModelPortal; Q4A589; -.
DR   STRING; 262723.MS53_0675; -.
DR   EnsemblBacteria; AAZ44082; AAZ44082; MS53_0675.
DR   GeneID; 3564469; -.
DR   KEGG; msy:MS53_0675; -.
DR   PATRIC; 20026032; VBIMycSyn118523_0717.
DR   eggNOG; COG0571; -.
DR   HOGENOM; HOG000246808; -.
DR   KO; K03685; -.
DR   OMA; CEFGFET; -.
DR   OrthoDB; EOG6T1WVS; -.
DR   BioCyc; MSYN262723:GH37-703-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRNA-bd_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   PANTHER; PTHR11207; PTHR11207; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
DR   TIGRFAMs; TIGR02191; RNaseIII; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW   Metal-binding; mRNA processing; Nuclease; Reference proteome;
KW   RNA-binding; rRNA processing; rRNA-binding; tRNA processing.
FT   CHAIN         1    231       Ribonuclease 3.
FT                                /FTId=PRO_0000228552.
FT   DOMAIN       12    139       RNase III. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
FT   DOMAIN      165    231       DRBM. {ECO:0000255|HAMAP-Rule:MF_00104}.
FT   ACT_SITE     56     56       {ECO:0000255|HAMAP-Rule:MF_00104}.
FT   ACT_SITE    128    128       {ECO:0000255|HAMAP-Rule:MF_00104}.
FT   METAL        52     52       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
FT   METAL       125    125       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
FT   METAL       128    128       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
SQ   SEQUENCE   231 AA;  26235 MW;  BF47EE3F88964D7F CRC64;
     MEKDNQPSIE ELKAFLQKNN IEYKNIDLFI EATTHKTYSK VNKNSKDYER LEFLGDSLVG
     FLISDYCVRE FSSLEPGELS RLRSKLVDKL ALFKIAQKLK VEQIIKTGPK KARNEVLSSS
     NVLSDVVEAL IAAIYLDQGM QSAKDFIKSH FYEIANKAQN KPNKDPKSEL QEYFQTISAE
     TVKYETIEIP NKRSFESKAW HLNKIYGTGV GLSKKDAEKN AAANALSKLK T
//
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