ID Q4CMH1_TRYCC Unreviewed; 542 AA.
AC Q4CMH1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Phosphatidylinositol 3-kinase catalytic subunit, putative {ECO:0000313|EMBL:EAN81474.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053511709.19 {ECO:0000313|EMBL:EAN81474.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN81474.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN81474.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN81474.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN81474.1}.
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DR EMBL; AAHK01003411; EAN81474.1; -; Genomic_DNA.
DR RefSeq; XP_802920.1; XM_797827.1.
DR AlphaFoldDB; Q4CMH1; -.
DR PaxDb; 353153-Q4CMH1; -.
DR EnsemblProtists; EAN81474; EAN81474; Tc00.1047053511709.19.
DR GeneID; 3532409; -.
DR KEGG; tcr:511709.19; -.
DR eggNOG; KOG0906; Eukaryota.
DR InParanoid; Q4CMH1; -.
DR OrthoDB; 123948at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT TRANSMEM 51..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 416..491
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT NON_TER 542
FT /evidence="ECO:0000313|EMBL:EAN81474.1"
SQ SEQUENCE 542 AA; 61428 MW; EE837B11AD4F4340 CRC64;
MGCGHAFILR LYACSFFFFF FSNQTKAIQG VFSLKFILRL CALYKYTYDF FFFLLAVLFP
VSFFFFFFFF SFFYVSLILW LGQRVRYHFA PSGVRERMEG NFLRPATGMQ QAKTVEDETN
QPLSKGVELM TYDSYDFGML AIDVVLGDGT RCMLDFSESL YLGRLLSMRP PVVFSFGSAT
AMRELEKIVA LLHGTRHTGS SYATDECDSG LKNATMRSHG MADAAAGMGM SASAAPPVEL
SASDRIAVVR AHVRQMSENR RLFMDVLELA TRLEMEETFP LLCEEFSFIF ENEVRGKFTK
SLFLLQELGG SGQMAIKTFR KIVMRAFALD GGVSPVPATR DEQRQPRPSN CDEVAHHWLK
QLREDHYFFP GGQLIGDLTQ SVDPEASVWR DETPFGDEFT PSFQRYPFHS PVWEPGDTAK
TCPVCGMIFA SWSTLSLNTV RPSHCRCCGR RICARCTSWQ LDKSIAKLNK PGVPEEGQLR
RACKECFDKA EKLNKHAFLC EIFVLAGLTL TEIALLRSIN PHWKGASELC LSDYRSSLYH
TP
//
