ID Q4CSG5_TRYCC Unreviewed; 754 AA.
AC Q4CSG5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN83217.1};
GN ORFNames=Tc00.1047053509513.10 {ECO:0000313|EMBL:EAN83217.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN83217.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN83217.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN83217.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN83217.1}.
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DR EMBL; AAHK01002134; EAN83217.1; -; Genomic_DNA.
DR RefSeq; XP_805068.1; XM_799975.1.
DR AlphaFoldDB; Q4CSG5; -.
DR SMR; Q4CSG5; -.
DR PaxDb; 353153-Q4CSG5; -.
DR EnsemblProtists; EAN83217; EAN83217; Tc00.1047053509513.10.
DR GeneID; 3534689; -.
DR KEGG; tcr:509513.10; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4CSG5; -.
DR OrthoDB; 3887240at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..446
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 81620 MW; 89ABEBA981154C98 CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGR ESEPQRPNMS RHLFHFVLLL LVVMMCCGTC
GAAAAGGNNG RSGLRNFRKL QRVDLFVPQT TLVLPKEGTS PETNRFSFVT PSLVSAGGVI
AAFAEGRVYA EYQGAQSITS FHSDVVARYI DSAWNWTTLV GTVNQSTWRA HIVLTAADGQ
KRFGGTLNPT TIAKGNKVFL LAESPGLSSV NDSLIRNSLH LTLVVGTVTN STGGEPSKRI
SWDNPKSLLS VNTSAASYES KFVRFFPSGG AGVLMEGGTL VFPVFAFDKY NHDYSMIIYS
TDDGANWMLS NGTSPAKCSN PRVTEWEGSL LMIVDCENGQ RVYESRDMGT TWTEAIGTLP
GVWTNSQLTV ILDPSLHVEA LIAATIEEKK VMLYTQRGYA SEGEAERALY LWVTDNIRSF
SVGPVAMEED DVNWKIASSL LYSDGNLHLL QQRGDYKSSV MSLSRLTEEL STIKSVLSTW
AKKDAFFSNL TIPTAGLVAV FSNALSGGDT WIDEYLCLNA TVTPNAKKVK YGFQLTEPSS
RVSWSVNTRG DNVRHVSLSH NFTLVALVTI EETPSGNTPL LTATLGDTNS NHAMGLSYTA
DKTWVTGLKG NKTTQNGSWE PKKGYQVALM LQGKKASVYI DGKLLGEEEV PLKGVAPLEL
VRFCFGACGE DAGQKTKVTV KNVFLYNRPL NSTEMRAIKD KAHTLNGPGE ALAGWAALEG
AAAREHAAVV GLTSAGSGLL PLLLLLGLWG LASA
//
