ID Q4CVY4_TRYCC Unreviewed; 638 AA.
AC Q4CVY4;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Carbonic anhydrase-like protein, putative {ECO:0000313|EMBL:EAN84436.1};
GN ORFNames=Tc00.1047053509597.20 {ECO:0000313|EMBL:EAN84436.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN84436.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN84436.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN84436.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN84436.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01001695; EAN84436.1; -; Genomic_DNA.
DR RefSeq; XP_806287.1; XM_801194.1.
DR AlphaFoldDB; Q4CVY4; -.
DR SMR; Q4CVY4; -.
DR STRING; 353153.Q4CVY4; -.
DR ChEMBL; CHEMBL4295601; -.
DR PaxDb; 353153-Q4CVY4; -.
DR EnsemblProtists; EAN84436; EAN84436; Tc00.1047053509597.20.
DR GeneID; 3536250; -.
DR KEGG; tcr:509597.20; -.
DR eggNOG; KOG0382; Eukaryota.
DR InParanoid; Q4CVY4; -.
DR OrthoDB; 49814at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd03124; alpha_CA_prokaryotic_like; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR041891; Alpha_CA_prokaryot-like.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF266; CARBONIC ANHYDRASE 1; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..638
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004236277"
FT TRANSMEM 594..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..314
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT REGION 535..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71129 MW; 3937AF9A836F75AE CRC64;
MTCGIRRGEG REGSKMVKAV IFSLLCLHVH ALMSPVSAEN GYTTAGLPRE KPQGPQWGYT
NLTAWPKLCQ TGKQQSPVSF SELQPNEVVH RKDMGPLVFS RDCKFAAEKT SLKIENEVNT
ISVRFIPLDD PTNKFPSLCT VRDPTDPDSP EYHLVSMHFH SPAEHVLPCA NPDAELHLVF
AHTQQSRQPH LMVVVVQLVA SDKINSTSVA ALKHILLDGS LPPKRAVTTC TLTENMTIAG
FLPQSGSYFA YNGSLTTPPC TEGVLFVVLT SPQIISKTAL ERLVEAFQRA RPGNHNGNHR
PTQPLNGRVV YHFVDMHHMN YSMCMRDMEN HHTNSSQMAG MSGAMQHMNC SMCMRNMENH
HKNSSQMEGM SGAMQHMNCS MCMRNMENHH KNSSQMAGMS GAMQHMNCSM CMRNMENHHT
NSSQMAGMSG AMQHMNCSMC MRNMENHHKN SSQMAGMSGA MQHMNCSMCM RNMENHHTNS
SQMAGMSGAM QHMNCSMCMR NMENHHTNSS QMAGMSGAMQ HMNCSMCMRN MENHHKNSSQ
MEGMSSEEMS MMERSANESS GAQLAGLASE ENATNTSSAP ANKWPHQFNS RERLFLIAAA
LVLLLVTFIL YRWRNSSARE TETESLFRSH EGYGTTNP
//