ID Q4CW39_TRYCC Unreviewed; 633 AA.
AC Q4CW39;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN84489.1};
GN ORFNames=Tc00.1047053503667.10 {ECO:0000313|EMBL:EAN84489.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN84489.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN84489.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN84489.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN84489.1}.
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DR EMBL; AAHK01001675; EAN84489.1; -; Genomic_DNA.
DR RefSeq; XP_806340.1; XM_801247.1.
DR AlphaFoldDB; Q4CW39; -.
DR SMR; Q4CW39; -.
DR PaxDb; 353153-Q4CW39; -.
DR EnsemblProtists; EAN84489; EAN84489; Tc00.1047053503667.10.
DR GeneID; 3536317; -.
DR KEGG; tcr:503667.10; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4CW39; -.
DR OMA; ILMIADC; -.
DR OrthoDB; 132144at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 18..369
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN84489.1"
SQ SEQUENCE 633 AA; 68535 MW; 30997B3867B74B18 CRC64;
LAGGDDSKSG VGVSFVSPSL VSTGGVMAVL AEGIISYNPS SAKETFVYHS DIVAGYVNPA
ESWPSLVAEI NDGTWRAHTV LSTVNEERRV GIARLPTTIA KGNKLFLLVG SYIMMQDTKD
DFWKLGGTDI QLVQGEATNS AEGKQSKSIK WGEPKSLLGQ IAPQAQGDSK VLWAGGGGSG
VLMEDGTLVF SLQKRKENGE FLSMIIYSTD DGSSWALSKG MLPAGCRGSC ITEWERGQIL
MIADCDNGQR VYESRDMGET WTVSFRTLLG VWVNSESAFF WDKSLRAGAL ITATIEGRKV
MLYTQKRYPT EEQKDKALYL WVTDNNRTFH LGPVAMDSAE NKTFDNALLY SDGELYLSQQ
RANEKDSVIS LSRLTEELST INSVLSTWVQ SDDSFSDSST PTVGLVGFLS DAASGDTWID
KYRCVNATVT SAAKVHNGFK FTGPGSGAIW PVNSREDNNQ YGFVDYNFAI VATVAIHQVP
KESTSLLGAS LVEGHPTKII GLSYGAGRKW ETVFYGKTTA QDSAWEPGRE YQVALMLQGG
NKGSVYVDGK LVGSSETIPT LETTVLEISH FYIGGDEGGS GSDLTVKNVF LYNRPLSADE
LKMVTKREDS VRGGVSRVLP LLLLGLCGIA ALY
//
