ID Q4CX43_TRYCC Unreviewed; 551 AA.
AC Q4CX43;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Dihydrolipoamide dehydrogenase, putative {ECO:0000313|EMBL:EAN84842.1};
GN ORFNames=Tc00.1047053508933.10 {ECO:0000313|EMBL:EAN84842.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN84842.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN84842.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN84842.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN84842.1}.
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DR EMBL; AAHK01001573; EAN84842.1; -; Genomic_DNA.
DR RefSeq; XP_806693.1; XM_801600.1.
DR AlphaFoldDB; Q4CX43; -.
DR SMR; Q4CX43; -.
DR STRING; 353153.Q4CX43; -.
DR PaxDb; 353153-Q4CX43; -.
DR EnsemblProtists; EAN84842; EAN84842; Tc00.1047053508933.10.
DR GeneID; 3536768; -.
DR KEGG; tcr:508933.10; -.
DR eggNOG; KOG1335; Eukaryota.
DR InParanoid; Q4CX43; -.
DR OMA; SHAFAKC; -.
DR OrthoDB; 5486579at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
DR PANTHER; PTHR22912:SF222; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR22912; DISULFIDE OXIDOREDUCTASE; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF02852; Pyr_redox_dim; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 25..362
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 389..485
FT /note="Pyridine nucleotide-disulphide oxidoreductase
FT dimerisation"
FT /evidence="ECO:0000259|Pfam:PF02852"
SQ SEQUENCE 551 AA; 60401 MW; 38498EEFD559B051 CRC64;
MLRRSWAWRK MPVEVTRNTS KLPHFDVCVI GGGPAGVAAA LRAVDYRKRV CLVEASRVGG
VDLWDGTLQS KTLWEMAKYA SRLSGPAAQR LFEEDAVAGV KNKISDARVL QALQDVSGVR
EQQLLDALRT AGVEIVFGKG MFSSPNELDV HSTGSGVYNV VRADYFIIAT GGVPRTQFHM
EADGRRIVTT ETIMRLPIPS SLVIIGAGAI GCEFASIYAN LGRTKVSLVD RTPRILQVED
EDISQFVQDQ LVRLGVTIHS NCTLFDLESW GDNEEEGGCI YSVRKNDIDV VSPVETYEAE
RALISVGRVP NVSGLGLENT SCKVTDGRLV VDAFNRCLPH KHIYAIGDVC ARRALVNLGE
AQGRGAIDHI YSEKPEKSIN AEALTNLSTI LFLDEELACV GLNEQQCRAR SLGYIVARYG
YGHLSRALAM GNTTGFCKVI VTSDSEKRLL GVRAFGVHAG SIIEVASLSI RRLESAYELL
KLTPSYPSAV QGLVECIRMI LGRSALKPNT TPDATLKVWH PPHFRRGREY IDETGYEESV
MNSDDVKIAR T
//
