ID Q4CYP6_TRYCC Unreviewed; 422 AA.
AC Q4CYP6;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=Tc00.1047053503657.50 {ECO:0000313|EMBL:EAN85398.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN85398.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN85398.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN85398.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN85398.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01001434; EAN85398.1; -; Genomic_DNA.
DR RefSeq; XP_807249.1; XM_802156.1.
DR AlphaFoldDB; Q4CYP6; -.
DR STRING; 353153.Q4CYP6; -.
DR PaxDb; 353153-Q4CYP6; -.
DR EnsemblProtists; EAN85398; EAN85398; Tc00.1047053503657.50.
DR GeneID; 3537444; -.
DR KEGG; tcr:503657.50; -.
DR eggNOG; ENOG502RYD8; Eukaryota.
DR InParanoid; Q4CYP6; -.
DR OMA; PILHSAC; -.
DR OrthoDB; 75723at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:UniProt.
DR Gene3D; 3.90.70.200; Plus-3 domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004343; Plus-3_dom.
DR InterPro; IPR036128; Plus3-like_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF03126; Plus-3; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00719; Plus3; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF159042; Plus3-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 375..410
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 169..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46175 MW; E9068467CD133D63 CRC64;
MLSEEDQLLF VAAKEAQLTR NEAVHIIMSD VSHSVFYGAF IRVLLELQDH REDYIVARVG
AIATGEVYGG FSNNANIRTD NYLVLQLPPH LAKINGTQYQ LNSISNSPMT EGEFSRWLEV
ARSGAHALSS LYALEGVAPV ALSVPTREEL AAVAWRLRGV IGNLARHGHG AHRQRRCSQV
QPSQAQEQGP ATPPPDNLLQ ALSGCPSRHA PPSEGNFSAP ILHSACAADN AYNHDDVSNF
ARQITTASLG PANSNISQQQ PYNPIYLQQA GNINGSVEGS GPSENPPLFQ GALSPIPVST
SPPTAIEISV AERELELPTR RQIRQDIINK MNQSGVLFPT NINELKVSQL RLAERDMIEY
LEQVREAISS KQENCVVCMD HVPTVISLPC RHKVLCRLCA PSVSTCPVCR SQLFELFEPK
EI
//
