ID Q4CZJ8_TRYCC Unreviewed; 894 AA.
AC Q4CZJ8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN85698.1};
GN ORFNames=Tc00.1047053504201.30 {ECO:0000313|EMBL:EAN85698.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN85698.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN85698.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN85698.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN85698.1}.
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DR EMBL; AAHK01001368; EAN85698.1; -; Genomic_DNA.
DR RefSeq; XP_807549.1; XM_802456.1.
DR AlphaFoldDB; Q4CZJ8; -.
DR SMR; Q4CZJ8; -.
DR PaxDb; 353153-Q4CZJ8; -.
DR EnsemblProtists; EAN85698; EAN85698; Tc00.1047053504201.30.
DR GeneID; 3537799; -.
DR KEGG; tcr:504201.30; -.
DR VEuPathDB; TriTrypDB:TcCLB.504201.30; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4CZJ8; -.
DR OrthoDB; 2877710at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..448
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 13..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 95602 MW; F727D9BD3B2BB059 CRC64;
MLSRVAAVKA PCTHNRRGVT GSSGRRREGG ESEPQRPNMS RNLFYSAVLL LLVVMMCCST
SGAASSKDVP SAPGSSKKES FIWRDVKEGE KAGLLRVPSL FEMNGDFFAV AEAQWKEKNG
NEGDFTGIAS QLLKLSDGQT SKELDKNKLK TQVLEECSAK NKVCASQAGD REASQSRTKV
RVSRPTTVVK ESDIYMLVGR CSRTAAGKKS GANDGGLLLA KGNVSGESSN KRIYWNGIDA
LQSTYNTQHE SLTRLIGGGG SGVKMEDGTF LFPVEATKKD EKTVSLILYS KDTQNWKLSN
WMSADGCSDP SVVEWKDKLI MMTACDYGRR RVYESGDKGD SWTEALGTLS RVWGNKHDEN
VKLVRGGFIT AKIEDRDVML VTLPVYANTE SEEKEKEKGE LHLWLTENTH IVDIGPVSGD
DEDAAASSLL YKSAEGEDRK EELIALYENK KGDEEKSLGM VSVRLTDQLQ RVKDVLATWN
KVDERVSQLC LNSLSQKGLS TQSVCTGKIT AGLVGFLSGN FSDNTWRDEY LGVNATVAEK
DGAQKADKGV TFKGRGAGAE WPVDAQGENQ LYHFANYNFT LVATVSIDKV PEGDNTIPLM
GVKMKGEQEK LFGLSYEKEN KWQLLCGDAT TNSGELSSIG EPETTHHVVI LLRNGNQSSA
YVDGQRVGGD APCTLGSTDL REISHFYIGG DGVSAEDKES REGVSVTVTN VLLYNRPLAS
EEIAELAKNK ITITKPEEPK KLTTRPRSPA VSATGVEGTV SLSNAAGQQP SEHEPLTANI
GAGVLSSATS IATTPSPDAD PTVVTVGGET VQGDGSLQTP GVSVSSGADG ETAGGTDAQQ
EGIHAQAGEV TATALNSSLG NVSQGNNTDA GTVRGSGLLP SLLLLLGLWG FAAA
//
