ID Q4D038_TRYCC Unreviewed; 931 AA.
AC Q4D038;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN85892.1};
GN ORFNames=Tc00.1047053504031.50 {ECO:0000313|EMBL:EAN85892.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN85892.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN85892.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN85892.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN85892.1}.
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DR EMBL; AAHK01001330; EAN85892.1; -; Genomic_DNA.
DR RefSeq; XP_807743.1; XM_802650.1.
DR AlphaFoldDB; Q4D038; -.
DR SMR; Q4D038; -.
DR PaxDb; 353153-Q4D038; -.
DR EnsemblProtists; EAN85892; EAN85892; Tc00.1047053504031.50.
DR GeneID; 3538022; -.
DR KEGG; tcr:504031.50; -.
DR VEuPathDB; TriTrypDB:TcCLB.504031.50; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4D038; -.
DR OrthoDB; 5592866at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 93..440
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 98474 MW; 1131740A8B5063A2 CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGR ESEPQRPNMS RHLFCSAVLL LIVVMMCCNT
GGAAEAAEQS SGPNYKWKDV KDEEGVTVES LGVPGLLKVG SDIFAVAEAQ CKKKEGQGSF
TGIASQIITK DNADTPVELL NGVKDKTQVL EEDGSEDPKK RIDVSRPTTV VQGNDIYMLV
GKYSQTAATG QEDGGADDWG LLLVQGNVSD ESGGEKRIQW NENQRLVGAF AADEHKCLTH
LIGGGGSGVH MGDGTLVFPL EGTKKGEAQN DEKAVSLIIS SSSSTKSWML SKGMSDGGCS
DPSVVEWKGK KLIMMTACDD GRRRVYETGD KGDSWTEALG TLSRVWGNKQ GAKAVRSGFI
TATIGGVDDK KKVMLVTLPV YSIKDGKKEN GELHLWLTDN THIFDIGPVS GEDKDVATSS
LLYKGAGSGD KKDELIVLYE KKKDDGEKPS HSLWSVVLTE QLQRVKDVLA TWKKVDDRVS
KMCPSKSAVE STSPENACSP TVKITDGLVG FLSDNFSDGT WRDEYLGVNA TVKNNDDGGK
KATLHEGSVK FQGAWAEWPI GRQGENQLYH FANYNFTLVA TVSIDGAPQE GDTRIPLMGV
NMNDDGKTVL LGLSYNSGGK WELSCGGENP EDQSRTWEKA KKKHVVILLR NGTQGSAYVD
GERVGGDAQC ELKVTESNEI SHFYIGGDER SAGGAGIQDV SVTVTNLLLY NRPLTLEEIG
ALNPNKVLIP PVVSDNAQGT LSQSSPAGQP PSGPKLLNGN EGAGGGSTST SAPSTATTSL
GKEQSVIRLP LGTSSGGNKN VDVASPSDGD PTVGAEAGGA VQGDTPPQTP VDTPDTADPN
APTATNVAQV DPADTTEVGA RSGENGETVG GTDGQKREDI HAQDGEVRAA ALSSSLGNVS
QRNNSDAGTV RGSGLLPSLL LQLGLWVFAA L
//
