ID Q4D157_TRYCC Unreviewed; 1125 AA.
AC Q4D157;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Dpy-30 motif containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Tc00.1047053507209.30 {ECO:0000313|EMBL:EAN86258.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN86258.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN86258.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN86258.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN86258.1}.
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DR EMBL; AAHK01001258; EAN86258.1; -; Genomic_DNA.
DR RefSeq; XP_808109.1; XM_803016.1.
DR AlphaFoldDB; Q4D157; -.
DR STRING; 353153.Q4D157; -.
DR PaxDb; 353153-Q4D157; -.
DR EnsemblProtists; EAN86258; EAN86258; Tc00.1047053507209.30.
DR GeneID; 3538458; -.
DR KEGG; tcr:507209.30; -.
DR eggNOG; KOG3078; Eukaryota.
DR InParanoid; Q4D157; -.
DR OMA; CALAFMC; -.
DR OrthoDB; 156889at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR CDD; cd22967; DD_AK7; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR047499; DD_AK7.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12239; PROTEIN CBG20215-RELATED; 1.
DR PANTHER; PTHR12239:SF41; TOLA PROTEIN; 1.
DR Pfam; PF05186; Dpy-30; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT REGION 44..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1008..1035
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 177..196
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..609
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..659
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..724
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 129085 MW; 53756B2FA35BB6C8 CRC64;
MKRVLVLNVD SFVGREVCRC FFDAKEYLVD GTLYHFQSTR ENPEAKESLR TDGLDSAGKM
KPHCATASTS SVRLDVPPDM RPFLNSVMPR HGDISDEQFR VRVLTYDIII AILEEDAFEA
DCAIKVLRGT HYEVEKTFVL VSNVFTWTQT DAHERELRRA ARRAEREAAR AQRYEDDVIE
EEEEEEEEEE EEMEQKVWTE EDYRQRYPDL RYHLWKDLEH AVKHANSETL HTYVLWAGLP
YGRGEDLLVS HFNAAWRHQE MLQYGDGSNY IPTIHVKDLA RIIYLVGSSY DTLEDRYMFA
VDQGNNTQSD ILQGIKDFIG GVVSVTAPEI DRKNQVVIPG NQKKGGREAD VKENELAEEI
QHEHDVLVGL GMREAQVLDE EKEEMLRIKE ISQREKLLRL GLGVQEIEND DDTNHALRPE
AASKVGASLT IAPPHGLANW FSAVDMRCEP GAVLALLEEE EWVSLGGFFA NVDKIVQEFK
AARQLRPMRL VLSGPPLSKV GEVAGVLAEL FNIPHLTLAN VTAAYEEHVR SLREELIGIL
VLRQLRRHTA REERRRREKE RAKEARRKAR EEEGEEGEEG EEGEEEEEEE EGEEEGEEGA
EEEEEKGEEG TPAAQDLDPA ERIRAAITEA MLLRVPEDEE EEEEDDSHYN ADDEEEVDEK
AAAMAQQVDE AERRRIATLR EEYRFATQLL SLRLLNGEFP RRPKSADEEE EGEEEEEYDE
YDDEEEYMNR KKRREQKKDV KKDVTEEPPP TIRYFDEVMA VMVRWRLRQE DCKNQGYILE
AFPETVRQAW LTFLADTEEQ KEMQRPKLQK VRDEEAVPQP LLDANFPLPV LADLEEDRKQ
EIMELMTGRR FASAEEVLVP THDTFFPDCF IALTGNEVTL RSQIYAAIAT ATPGDTTPDF
SEQFTRYMTH NRPGAPPTES LICWFQTVVA ERVDEDGDVA VATEGGELRE KVPRKACVLF
VPVFSTFPQA VLPKFFNHEE ISGMRAYCTF IRSEILKNIG LDSCGSVIDS MRAEAEANKS
RVQELASERE KLEKLSASDK LFAAAAQKLE DDFLENERRA LRFYQAKEEL ASIVGIDSIP
VDVYLMRYVM PSLTPLMAEV VRMRPEDPVT VLADALFHHK RQVSL
//
