ID Q4D211_TRYCC Unreviewed; 1009 AA.
AC Q4D211;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Protein kinase, putative {ECO:0000313|EMBL:EAN86563.1};
GN ORFNames=Tc00.1047053508503.60 {ECO:0000313|EMBL:EAN86563.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN86563.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN86563.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN86563.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN86563.1}.
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DR EMBL; AAHK01001192; EAN86563.1; -; Genomic_DNA.
DR RefSeq; XP_808414.1; XM_803321.1.
DR AlphaFoldDB; Q4D211; -.
DR SMR; Q4D211; -.
DR PaxDb; 353153-Q4D211; -.
DR EnsemblProtists; EAN86563; EAN86563; Tc00.1047053508503.60.
DR GeneID; 3538829; -.
DR KEGG; tcr:508503.60; -.
DR eggNOG; KOG0198; Eukaryota.
DR InParanoid; Q4D211; -.
DR OMA; MPHPRVT; -.
DR OrthoDB; 166908at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06606; STKc_MAPKKK; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF29; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1A; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:EAN86563.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transferase {ECO:0000313|EMBL:EAN86563.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 146..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 733..978
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 762
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1009 AA; 112173 MW; 847D14E59BCDD9CB CRC64;
MLPHPILATE DDRDYIERSI LSMQEHVENF FALLELVYLE SKSEQTPRAH ALFHSIQSTL
KVLGTVPSSS YRKNDSKLTV DEELPKGLER MRRLFFDVVT VGPESLVWKK PVTRLAQEAA
QHAKNIQIKF PSSSTLVRKG VSRNSFCFLL LILIFVSALI LALVTMVVIP FIGPSPSVAA
AVGILSAVFL VGSGSCIIFC FVMAVRALQE LFDRLLGERM HANLIYQPSS GLSDEASPCN
TTTNQLRVKR GRDTRRGYYA IPYGDCVGYI EGKHVDAHVV MIGFDSNYLI TRWNMAAEVM
TGFLEGGCIG KPLSDLLITP SGDVPHDLST LQASKGDVLK VKLRAFATAP VTLCTIAAPI
LNLSGKTIGS ILICANAKDN LGVFRSYIRD YLTSEVSVSL SELVEKNAVD PQGKAAISSL
QSFLTCALDK QVQEMAREML TEWEWTTAEQ LLAQALRSFT VRHEKQIDSM FPATLCLHPN
VPKAISTLLD TIGVSCMVKL EVMSQTVNVF ALAVTITPHC EENELCLNEE ELQDAIMPLI
RSICGNMCKD GKDINLRFPC QVTAFLEDGE DAFKAIEKRG EQSIIDQTRA IVNCTVNVLA
LITDLVDQHN LSMILLKTMF VSLTTVRQRD DLERRLKAAP NDVDVIICDR GWLNSARDLI
ISSDHSAIVV PMADQGVFFA PEEFQYVIRS PISGNEVRKV LMDIGTAVSL RKNAATAREE
RERILTLRQD SPWTKGKLLG RGSFGAVYEA MSDLTGGKMA VKMFYFSADC DESINKLLNE
IRIMCSLNHP NIVHYFHCER KENNINLFME LCDASLGEII IGRKPVPPTL TVVQILRQVL
TALTYLHTRG VAHRDVKPQN ILLKGDTIKI TDFGTAREGK ASKDVQGTLR YMAPEVYRGE
AHSSPCDIWS VGCLACELFA CPPKFMDNSL ILAEMTSAVP YLENVTSSVT LNDFLRKCFQ
DDPEKRPTAA DLLLHSIFSP EFSYEVESLL TVFKKKLMRN YSFSITSQK
//
