ID Q4D3W4_TRYCC Unreviewed; 930 AA.
AC Q4D3W4;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN87211.1};
GN ORFNames=Tc00.1047053508375.20 {ECO:0000313|EMBL:EAN87211.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN87211.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN87211.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN87211.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN87211.1}.
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DR EMBL; AAHK01001070; EAN87211.1; -; Genomic_DNA.
DR RefSeq; XP_809062.1; XM_803969.1.
DR AlphaFoldDB; Q4D3W4; -.
DR SMR; Q4D3W4; -.
DR PaxDb; 353153-Q4D3W4; -.
DR EnsemblProtists; EAN87211; EAN87211; Tc00.1047053508375.20.
DR GeneID; 3539618; -.
DR KEGG; tcr:508375.20; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4D3W4; -.
DR OrthoDB; 2877710at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 92..446
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 97776 MW; EB73C45767400CC5 CRC64;
MHSRVAAVKA PRTHNRRRVT GSSGRRREGR DSEPQRPNMS RHLFYSAMLL LLLVLMCCGS
GAAGVAGQPS GPQFEWRGIT DGGGVTVESL GAPSLLKVGN DVFAVAEAQC KKNGESDIFT
GVASQPLTTK TANTPEEVLK KPKGETRVLE EGASEDQKKK VDVSRPTTAV KGSDIYMLAG
AYSSKVATPG QVGASDATQL GLLLVKGSVN SEDANNKKID WKVTESPPQR LFGTQPDSWT
KLIGSGGSGV KMHDETLVFP VEGTKKAVEG TEEDGKTVSL IIHSSDNTNW KLSKGISDGG
CSDPSVVEWE DDKLMMMTAC DGGRRRVYES GDKGESWTEA LGTLSRVWGN NKKGEEAKTV
RSGFITATVG NDGDKRNVML VTLPVYADND KEKGKLHLWL TDNTHIVDIG PISGDDDKDV
AASSLLYNSG ENTNEKKEDE LIALYEKKDG GKPSPGMVSV LLTEQLKRVK DVLTIWKEVD
KRVSQLCTSL IAEKERASTD DVCSAVKITA GLVGFLSGNF SDKTWKDEYL GVNATVNNKE
GAVQVENGVK FTGRGAGAEW PFGSQGENQL YHFANYNFTL VATVSIHKMP EGDTPIPLMG
VRAGSNGDEN NVLLGLSYDS EKKWQVLCCD GKTEELSSTL GTDKTYQVAI MLRNGTQGSV
YVDGQRVGGN EECELGNGES KEISHFYIGG DGVNAANKEG VSVTVTNVLL YNRPWDDTEI
AAFNPNKAPI EVQVDGSIEG NAIETSPGGG RPEEQRQSLG SSGADGVSAS TVSSARTSSG
GEGSATQLVS EESFDGSKNV GGASSPGSDA AVETGDRSTV QGDGSSETLV GTPATADAYA
PNAEAMGHDG TAVNPGASAS SGADGETAGG TNGQEKEEIH AQNGDVKAAA LSGSLGNVSQ
GNNTDACSVC GSGLLPSLLL LLGLWGFAAL
//
