ID Q4D7D2_TRYCC Unreviewed; 686 AA.
AC Q4D7D2;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 94.
DE SubName: Full=Thimet oligopeptidase, putative {ECO:0000313|EMBL:EAN88423.1};
DE EC=3.4.24.15 {ECO:0000313|EMBL:EAN88423.1};
GN ORFNames=Tc00.1047053511237.10 {ECO:0000313|EMBL:EAN88423.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88423.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88423.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88423.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88423.1}.
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DR EMBL; AAHK01000886; EAN88423.1; -; Genomic_DNA.
DR RefSeq; XP_810274.1; XM_805181.1.
DR AlphaFoldDB; Q4D7D2; -.
DR SMR; Q4D7D2; -.
DR STRING; 353153.Q4D7D2; -.
DR MEROPS; M03.011; -.
DR PaxDb; 353153-Q4D7D2; -.
DR EnsemblProtists; EAN88423; EAN88423; Tc00.1047053511237.10.
DR GeneID; 3541015; -.
DR KEGG; tcr:511237.10; -.
DR eggNOG; KOG2089; Eukaryota.
DR InParanoid; Q4D7D2; -.
DR OMA; RSGAWCS; -.
DR OrthoDB; 735202at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06455; M3A_TOP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 228..685
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 686 AA; 77603 MW; 6A40EF0C1E5E365A CRC64;
MRMALRIFAD VETASKCAVL FPKNVSACQV VAEEAKLRAM EKLNAIYSFE GNRTFDNTAV
AADIAAAEFD VSLSLLSVIM SVSTVKEIRE EANKQIVELK SFEIDNFQSN KRLFEALKEV
SQSSQYKEKY LEGNKDKEYS YWLDEELRNF RRKGMELPDN KFQEVVALEK ELSALCTTFS
RNISEDQSEI LASAEELKGV PVSIIDGLKK ADDGRFILKM DYPTFFGVMK NCEVAATRQS
MARAASNKAY PVNERVLKEI IAKRQALAEL LGFSSYSHLN LSDKMAKSPD VAKAFVDELI
PRLQQKWKHE LELIKKNLHE SCILTEDGRL REFDVAFMMN QIKKIHLNVS ETEIQEYFPL
DVTVKGLFDI YQAFFDITFT RIDNGFELWH ESAFTLQVKD NATGKTLGHV IMDLFPREGK
YSHACCHSVV PPVLLHGSED EFSPALGVVI ANFPAPLKDC PSLFLHDDVT TFFHEFGHAI
HGLMGRSRMA TFAGTNVKWD FVELPSQMLE EWVWEPEILQ KITSHYKTHE CLPSNLVEAK
VKSRNAFIGR DSLRQLEFAT YSLEVFSAPF AGGKDPNKLD TAELMRSIRS RISPDIKCED
DTHFECGFGH LTGYGAGYYG YMWSKVFALD VYEYIKSRNG LLDPVLGNHY VSNIIGIGGG
QDPTAMLKKF LGREPNSDAF LKTIGV
//
