ID Q4D8L5_TRYCC Unreviewed; 568 AA.
AC Q4D8L5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Histone acetyltransferase, putative {ECO:0000313|EMBL:EAN88870.1};
GN ORFNames=Tc00.1047053509203.60 {ECO:0000313|EMBL:EAN88870.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88870.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88870.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88870.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88870.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000819; EAN88870.1; -; Genomic_DNA.
DR RefSeq; XP_810721.1; XM_805628.1.
DR AlphaFoldDB; Q4D8L5; -.
DR SMR; Q4D8L5; -.
DR STRING; 353153.Q4D8L5; -.
DR PaxDb; 353153-Q4D8L5; -.
DR EnsemblProtists; EAN88870; EAN88870; Tc00.1047053509203.60.
DR GeneID; 3541559; -.
DR KEGG; tcr:509203.60; -.
DR eggNOG; KOG2747; Eukaryota.
DR InParanoid; Q4D8L5; -.
DR OMA; FAGFFTW; -.
DR OrthoDB; 127450at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF214; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 151..547
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 386
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 568 AA; 64261 MW; 87802ED67B8C46E7 CRC64;
MEKNSDRKAE EYPRQSSILG TPCSVRGPDA TVRRGHLLEV RYLWTPAFLH VDTHAPLVTP
PLYGFVRLKD LNHRLSGWFS LEDIGLKEAK GGGGGGNAAA GTVSPPPCGS TRIHGPILNS
VYREVTLGMI RTRREEKLLD FFEERLLRDC RTPTTIRYFV YLCKFVFAPW YYAPYGIFHR
EYDPLAPISM ADQERQGLRL SEETGGINPF IRDAYLCPFS LRIYSTLEQM QHETRCYRAG
RLRPPGQEIY RDESRGFSMF EVNGSQKVTY CRHLFLLGKS FLENKLAGHD VHNYFFYVVC
LHHRHFPQYT DDPSAMYFVG YFTWEKQVAD NNLACIVTLP CFAGGATQQK DSGGSNGRPQ
LGHFGQFMIA ASYELAYRRK HVGSPERPLS DLGASAYDRY WRRVLVAWMH TLVTESTTAV
EVSDGDSTDD QSVIVEATTP AKGRRSKRSR AGSSDRNSEA DDDVDVRAAQ TETLKVTSVR
GIAQQVRLEE PDVLRTLLNM GFLHLNAEDR SLRLVIPVPF VRREYERARE QAKDQTRAEF
EASLLTSSGA AAVMASSRQQ QKQPGVAR
//
