ID Q4D8V4_TRYCC Unreviewed; 735 AA.
AC Q4D8V4;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN88957.1};
GN ORFNames=Tc00.1047053509075.50 {ECO:0000313|EMBL:EAN88957.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88957.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88957.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88957.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88957.1}.
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DR EMBL; AAHK01000804; EAN88957.1; -; Genomic_DNA.
DR RefSeq; XP_810808.1; XM_805715.1.
DR AlphaFoldDB; Q4D8V4; -.
DR SMR; Q4D8V4; -.
DR PaxDb; 353153-Q4D8V4; -.
DR EnsemblProtists; EAN88957; EAN88957; Tc00.1047053509075.50.
DR GeneID; 3541674; -.
DR KEGG; tcr:509075.50; -.
DR VEuPathDB; TriTrypDB:TcCLB.509075.50; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4D8V4; -.
DR OrthoDB; 130386at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 714..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..450
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 80250 MW; B933C632D9AD0515 CRC64;
MLSRVAAVKV PRTHNRRRMT GSSGRRREGS ESEPRRPHMF RRVFNSAVLL LLVVMMCSVC
GASNAVTSNS GNAQLPQGVD LFLPQMTPVQ PKDGIVPVTT RHSFISPSLV SAGGVIAAFA
EGQVYTIDAG RQKEKNSSDI VVGYIDATWD WSTLVGKVNE ITWKANTVLG TMDGADNRVD
FFYHPTTTTK GNKVFLLAGS DYEHKQTVGN QTYSGFKTQL ELVVGDVSDP TSSDPTESIK
WGEIKSPLNE STIAAHKGNL TGLLAAGGSG VLMEDGMLVF PVMAKSGKGD FYSMIIYSKD
NGSTWALSED ISPVNCTDPR VTEWKGSLLM IVNFKYGQSV YESRDMGTTW TAAAGTLPGV
WVNARSGGSW DESLRVEALI TATIGGRKVM LYTQRGDFSG EKSERALYLW VTDNNRSFYF
GPVGMDTTVK EEFASSLLYS DGKLHLLQQR DNGENSVMSL SCLTDEVSTI NFVLKTWAKK
DAFFSSLSIP TAGLVAVLSD AASDDTWIDE YLCLNATVTP NAKKVEDGFQ LTEPDSRVIW
SVNTPDDNVR HVSLSHNFTL VATVTIEEAP SGNTPLLTAT LADNNSNHTM GLSYTANKTW
ETGLKGETKP TTESRPWEPK KEHQVALMLQ GNKASVYIDG ELLGEEEAPL TGEAPLELVR
FCFGAYDQKE GHEQDSHVTV KNVFLYNRPL NFTEMAAIKD RRHIPRIEGV RANAPAGSGL
LPLLLLIGLW VFAAA
//
