ID Q4D9D2_TRYCC Unreviewed; 444 AA.
AC Q4D9D2;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Enoyl-[acyl-carrier-protein] reductase, mitochondrial {ECO:0000256|ARBA:ARBA00041058};
DE AltName: Full=2-enoyl thioester reductase {ECO:0000256|ARBA:ARBA00042123};
GN ORFNames=Tc00.1047053506627.20 {ECO:0000313|EMBL:EAN89127.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89127.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN89127.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN89127.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN89127.1}.
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DR EMBL; AAHK01000781; EAN89127.1; -; Genomic_DNA.
DR RefSeq; XP_810978.1; XM_805885.1.
DR AlphaFoldDB; Q4D9D2; -.
DR SMR; Q4D9D2; -.
DR STRING; 353153.Q4D9D2; -.
DR PaxDb; 353153-Q4D9D2; -.
DR EnsemblProtists; EAN89127; EAN89127; Tc00.1047053506627.20.
DR GeneID; 3541875; -.
DR KEGG; tcr:506627.20; -.
DR eggNOG; KOG0025; Eukaryota.
DR InParanoid; Q4D9D2; -.
DR OMA; YGYTQSK; -.
DR OrthoDB; 6213at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd08290; ETR; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43981; ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43981:SF5; PUTATIVE-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 48..111
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
SQ SEQUENCE 444 AA; 49847 MW; 99AF53845B4D0F8B CRC64;
MRRSASLFGL PTVRTVAAAG WRYHRHGKPE KVLQYERFRV PFNRSGSQVV VKMLAAPVHR
HDRNMISGNH GPVKALGFPQ VAGVEGVGVV EEVGASATLN LQEGDLVWVN NPAVGTWATH
IVTEADNLDV VPNRADVDIE YLASLSLFHT AYHLTNSFVS LQPNDVVLQT GASSSVAQIC
QGYIRARGAK LFQTLQLGRT EHAHLVSFFK MRGAFAVVPY NYVRTNYMRR LLSDVPPPKL
LLNHTCGNYA SSVVNLLGDN GVCVTYGSTS GKPMQIANMD AIARGIQFKG FFLPSWIRRH
TREARMRVHQ NVVESMTISQ GHGIFRAQRF KMDGDSPFAF SNAWDAPLGS RKPILRMVGE
YGEWRRPRSD QAAWNIGRAV WDDLLQQMWE SAGTTENPQS MKYYTPFKDI YSHFHDAKQT
KEMGHRDVFF RRPNAPRHNA AERA
//
