ID Q4D9I9_TRYCC Unreviewed; 380 AA.
AC Q4D9I9;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=TsaA-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Tc00.1047053506857.110 {ECO:0000313|EMBL:EAN89200.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89200.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN89200.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN89200.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the tRNA methyltransferase O family.
CC {ECO:0000256|ARBA:ARBA00033753}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN89200.1}.
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DR EMBL; AAHK01000774; EAN89200.1; -; Genomic_DNA.
DR RefSeq; XP_811051.1; XM_805958.1.
DR AlphaFoldDB; Q4D9I9; -.
DR SMR; Q4D9I9; -.
DR PaxDb; 353153-Q4D9I9; -.
DR EnsemblProtists; EAN89200; EAN89200; Tc00.1047053506857.110.
DR GeneID; 3541955; -.
DR KEGG; tcr:506857.110; -.
DR eggNOG; KOG2942; Eukaryota.
DR InParanoid; Q4D9I9; -.
DR OMA; IHIADHD; -.
DR OrthoDB; 5477652at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR CDD; cd05162; PWWP; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.30.70; YaeB-like; 1.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR023370; TrmO-like_N.
DR InterPro; IPR023368; UPF0066_cons_site.
DR InterPro; IPR040372; YaeB-like.
DR InterPro; IPR036413; YaeB-like_sf.
DR InterPro; IPR036414; YaeB_N_sf.
DR PANTHER; PTHR12818:SF0; TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12818; UNCHARACTERIZED; 1.
DR Pfam; PF01980; TrmO; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF118196; YaeB-like; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS01318; TSAA_1; 1.
DR PROSITE; PS51668; TSAA_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 61..145
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 179..345
FT /note="TsaA-like"
FT /evidence="ECO:0000259|PROSITE:PS51668"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 42305 MW; 9A1AB4BB444969E2 CRC64;
MVVMEQKDAV GPRSPGSGRI PRRGSSEDDD GDGVVGTVKS KNQAERNRPM RLGVRPHYFL
PGDIVWVRPA ALPYWPAEVV QAEVSTNSIT ARLFDPPALL SLQADGNFSR DHVTVSATKV
FFFDRLSTPE EVEVCIEQRL QRTTHNVSAY EADFQRAVLH ANRLVRIVLS PEKLQPRLIC
GVGVVHSLMR THISAPRQPH TTNFTPQTAV IKLRVGLENA VRDLRGFEFI WVLFLFSYAT
DADETGDANG PGVLDALQGG AQRRRRQGAE NSAGFKTMLV PPRDSQLRGV FATRSPHRPN
FIGISCVRLV AVQGLEVHIA DHDLLHGTPV LDIKPYLPYC DAHPNAKAGW VEELENSGRV
GADHKYDMQR MQVDRIFEDE
//
