ID Q4DBF0_TRYCC Unreviewed; 745 AA.
AC Q4DBF0;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN89853.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053509765.129 {ECO:0000313|EMBL:EAN89853.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89853.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN89853.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN89853.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN89853.1}.
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DR EMBL; AAHK01000700; EAN89853.1; -; Genomic_DNA.
DR RefSeq; XP_811704.1; XM_806611.1.
DR AlphaFoldDB; Q4DBF0; -.
DR SMR; Q4DBF0; -.
DR PaxDb; 353153-Q4DBF0; -.
DR EnsemblProtists; EAN89853; EAN89853; Tc00.1047053509765.129.
DR GeneID; 3542717; -.
DR KEGG; tcr:509765.129; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4DBF0; -.
DR OMA; ANEWWAY; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 106..441
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 745
FT /evidence="ECO:0000313|EMBL:EAN89853.1"
SQ SEQUENCE 745 AA; 81266 MW; 18C88F14B32669EE CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGR ESEPQRPNMS RPVFASAVLL LLVVMMCCGS
GAAHAVERNS GDLQMPQEIA MFVPNKTQVV PKSGGEGKVK DIFASPALVR AGGVMIAFVE
GRTKNKRFPE VIDLSSSDIV AGYIKAPETW QSLVAEVTKD DWQAHTVLES ANNSKYRVGV
ARLPTGITRG NKVFLLVGSY EEGREIDDDI WKTEAWNIKV IEGETTQSTE VQPTQPINWS
EPKPLFQTDS PNNKGDLKEF LGGGGSGIVM GNGTLVFPLT AKDENNKVFS LITYSTDDGQ
KWEIPEGVSS AGCRSPRITE WEEGTLLMVT YCEDGRKVFE SRDMGKTWTE AFGTLLGVWL
KSGPELLEVS LRVGALITAT IEGRKVMLYT QKVRHSLEVD EPNALHLWVT DNSRTFHIGP
FSVDSAENMT FANTLLYSDD GLYLSQAKGD HESTAVSLAH LTEELKTIKS TLSTWVQLDA
SFSNSSTPTA GLVGFLSNTT SSGDTWIDGY RCMNASVTKA ARVKNGFKFT GPGSRATWPV
NSRWDIKQYG FVDYNFTIVA TATIHQVPSE STTLLGASLR GSSGTKFIGL SYGANGEWET
VFEGKKTVHG GTWEPGREYQ VALMLQDGKK GLVYVDGVLV GSSAMLPTPE KRWTEVSYFY
FGGDEGESGS NATVTNVFLY NRPLNDTEIG HLNANKVSLP FMDKKPAKAS TATSQSVDTV
TTSVTTEKKA TAPAPTTVET LPKEE
//
