ID Q4DFS3_TRYCC Unreviewed; 744 AA.
AC Q4DFS3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=DNA helicase, putative {ECO:0000313|EMBL:EAN91365.1};
GN ORFNames=Tc00.1047053504125.10 {ECO:0000313|EMBL:EAN91365.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN91365.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN91365.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN91365.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN91365.1}.
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DR EMBL; AAHK01000530; EAN91365.1; -; Genomic_DNA.
DR RefSeq; XP_813216.1; XM_808123.1.
DR AlphaFoldDB; Q4DFS3; -.
DR SMR; Q4DFS3; -.
DR STRING; 353153.Q4DFS3; -.
DR PaxDb; 353153-Q4DFS3; -.
DR EnsemblProtists; EAN91365; EAN91365; Tc00.1047053504125.10.
DR GeneID; 3544568; -.
DR KEGG; tcr:504125.10; -.
DR eggNOG; KOG1000; Eukaryota.
DR InParanoid; Q4DFS3; -.
DR OMA; YENCSIH; -.
DR OrthoDB; 318617at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18010; DEXHc_HARP_SMARCAL1; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45766; DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45766:SF3; SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EAN91365.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 9..163
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 304..464
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 498..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN91365.1"
SQ SEQUENCE 744 AA; 81090 MW; 8ABF4513F266CA6F CRC64;
RPFQKKGVDF IIARGGRGMI ADDMGLGKTV QALAVAHHYR NEWPVLIVCP LSLVENWTKE
LMRFCSIPIG RIAIFQNSKV RVTDVHSAVI VPYSSLKSLD TQSTTFQVVI LDESHYIKTV
DSKRTVAALK LCRVARRVLL LSGTPTLSRP IELYPQLQTI MHPSWTPSKS LFAARYCNAF
VGRFGVDYLG HSHMSELHVL LQQFVIRRTK RELGNELPSK IRQLLYVYIT PKEKKALEKS
VSALRNSFRD GATLPTLGDV ASTTNMAQGT GGNLTTCTAG GVTATRNMTA FDLKIATARA
KIAAVQDYVK STTEQMVESG QKVIIFAHHQ CMMEAIREAV ESVQPKQPLD YIYITGETPA
AQREALTTHF RTSTNCHVAV LSMHSCGVGH NLTCATMVVF AELDWNPSTH LQCEDRVHRM
GQSSACVIKY LLAEGTSDSV IWPMLQTKLN VTHAVLEDSQ AGGEGWSAGA DTRRILRSDV
PLTPSSPEKK QLTLEGFLSH SGSRPSRPLT QSSDSNAEVL KTSDESPRAD TSPDTPFQSP
SAVAPAENVL FDIAKLRQQR EARKVFHSMP VLGTAGAGSS PVAAVTVTPP PPQIQRQVTL
HEVLTNHPAN SPTPKNSPQQ RTNFHVAVAA KSFNERSGAA HTSSCSSETT VCAPIVSHPV
KTLFLTRPAS ANSSSAASSV KPHAGASAAD LSVFSTASKE GSICLAPSPR SEEIRRYNAR
RTPFILGSTL EKRLRPDDME DQVS
//
