ID Q4DJA7_TRYCC Unreviewed; 3462 AA.
AC Q4DJA7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Dispersed gene family protein 1 (DGF-1), putative {ECO:0000313|EMBL:EAN92614.1};
GN ORFNames=Tc00.1047053505037.100 {ECO:0000313|EMBL:EAN92614.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN92614.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN92614.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN92614.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN92614.1}.
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DR EMBL; AAHK01000420; EAN92614.1; -; Genomic_DNA.
DR RefSeq; XP_814465.1; XM_809372.1.
DR PaxDb; 353153-Q4DJA7; -.
DR EnsemblProtists; EAN92614; EAN92614; Tc00.1047053505037.100.
DR GeneID; 3546000; -.
DR KEGG; tcr:505037.100; -.
DR eggNOG; ENOG502SEI3; Eukaryota.
DR InParanoid; Q4DJA7; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR021053; Dispersed_gene_fam_prot1_C.
DR InterPro; IPR021004; Dispersed_gene_fam_prot1_dom4.
DR InterPro; IPR021282; Dispersed_gene_fam_prot1_dom5.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF11024; DGF-1_4; 1.
DR Pfam; PF11038; DGF-1_5; 1.
DR Pfam; PF11040; DGF-1_C; 1.
DR SMART; SM00710; PbH1; 10.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3053..3079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3124..3141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3161..3182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3188..3213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3263..3284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3290..3309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3316..3338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3350..3375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2836..2911
FT /note="Dispersed gene family protein 1"
FT /evidence="ECO:0000259|Pfam:PF11024"
FT DOMAIN 2924..3201
FT /note="Dispersed gene family protein 1"
FT /evidence="ECO:0000259|Pfam:PF11038"
FT DOMAIN 3373..3457
FT /note="Dispersed gene family protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11040"
FT REGION 3419..3449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3462 AA; 359370 MW; 770E84DE5F82D4E6 CRC64;
MRSVVGACPR SRHRVQRRAI AAVRVALLVV LALVAAAAWM PAVHAVVLRL RGGTVDRAIT
VGRAVDTVLM DGVYITNGVA VVFDVPAMLP GALRIELRKC VCDGGAQIYV RGCSGEPASD
RSLEVSVSGL SGGYCSLVFV HNLPAHTNVT VRDSTIVTAG PMRYSQLSGL TDAVASPLVL
HATSLLQTQL RVSNTVLRSL QAGGSAVYVG GDVDLLSSAV VLDGVLLGAS GGPTASAMRV
ASSSRLSLRV YSVFSVTNVS VVSSSGGIVL GERLAVVDSV LRFVGVEGSV ASSLVRCDGG
TIDAGGWLDL HDVWAVGEAS SVASLSGVTL GGGAVSIARC AATGATLVSG LTITSGVVSV
QCNRAGGRVL QSSGDYRMAG LSSVSVVPCD GCAAALACFD ALTASFSDCV CSCRAGGVGE
ACLPFDVPPA RSGGGGGGAQ GCVSGVTLTE SVTVGGGQAT ACFDSVVFSG PITVAVDLRS
MDAFADALNV TLRHCVLAGG VRLRIGGLSE STARLMPHAL VNMTNVTSLE GTIVLHGAMP
LHSSVLLANS TLRATVGGSR YVPTTRGHEK SRYGPALVLD GVRLLSTRFV MTRSTLVCGG
GSCAAILVER GLDVKLSSVF YMDNCAVVSR VHVMYALALG LRVSSGSVFS IQNSSWSASS
IEYDDGACMF GDVVVDGGSV LQIVSSTFRL GFAMLIATTL TVTDGSWLVH RDNEFRTAYV
VYVESENGVA FRDRSVWSIL DNNFTYGSYS STIVSMTNDW SPPSDSRPTI YGVCNELRGS
PVTNYQDELN IGAPVTALDC GACTVDAVCF AAKTSSIRGC ECVCAAGGHG DTCLPAAVPD
GLGPLPLPDA RDTEVRCVHG GSISSVDVPD PGVRGLCFVN VTFTDEIVLD LWSFDAPQQT
LNITLLQCGL VGLSIRGCGA RVHVSVTSSM LDSGALEFEG DFCASSQILV AGSTLLSTVS
RAIAFSDFFF DANSTLLLLD NYIEGNIYAV YFSIGVVDGG GIIVKGNTLS TTEEDDGMES
CACVYAVDVK NGGYLDVEKN TMSAVSGIYF YEDTTVSSAG LLRVADCDFV GSAEFLDSAL
LYLAGSVALQ GGAQWRVEGN NVSAASVISI GHDQHKIQLS GSGTTVALAH NRQVDDIYPF
ADLDQSNLIV VSPAKIVVGC NLQGDEEVSY GGLFPEGVVI FRCGTCNEDA ACYMPGTESV
DRSSCSCSCK DGWHGASCLP FEVPDTVVPP VAERAVDGDT SCVVDQALTD LTLTMWKTHH
CYVGVTFSGV GAVLTFSFDS MPLHLPINIT LTGCTFREGA ALQFVGGAGA AESSGVLIRV
SRTVMRSSAV VFARALPQHC DIAVTEVDAV QSSAVHLPDT VNKMLSVVML HDVVLTASSL
LVSNVNAHAS RYDGFGLFST GTLTLVGGSS LYTRYCSFDG YTYLFYVNIL GVSDRSVFAL
LNNTMASGTS LLYQHSRFSV SDHSVLRVVG NSGTVSNAIV TDELWTVQRS SWLDWRDNDV
GVGAMFYDTE SAFVSIGSSG VVTLTGCKMG STGLSVSLLR WVRAGYRFVA GCLTVAGREV
TTAAELELHG ITNVTTVAAC GECTKDGDCF APLTTAVSDC RCQCAAGGHG EVCVPAPVPA
GPPPPPLPPL PVSPPLPVPP VGECISDMVY PEVAQAVGGG LSWLCYRNVT FSGDGMSLTV
LVGAMTGDVA NITFDGCTWR DGAVLLLLGN AYATVGALNI VVTGNTFRDA LLSPEGVFPP
HTNITISGNR FTVTRLIPRS GLDVDSPSCV VMNGLAISND SAVVLSGNVF QTVLASSSAI
HVVRSALRVS WQSVLAVVGN TFHMDGSNGT LIYLEGSSQT SSLDVLNKSA VVVRGNLVAR
PVQYFMHILS TLRVESLSAV VFHGNDMQGS LAVFYSTFTA NIYYNSWLQL SGNLCRESPL
YAFTLFDPRV NLRDSTVSVS GNKFMSSTVT PTVLLILKKS RDLTNGAIVA ACNTVNGEGE
AKYAIPSVYN ATILTCSDPC TLAASCFPAY TTTASSDGCA CRCDEGGHDD ACLPVAVPEP
PSTDGADLCV RDVCVDVEVN AGFGISVVCY VGVTFAADVV VDVEPMSGSV RNVTLVNCTF
VDGASLYVVG WLSDPPAGQR VDVLVSGLES RSGGGVLVAN RYPPGSRVAV VDSVLIAEKH
VAYRGAYGLG DASACLVVHN VNLTGSVLTI ARTHVAAVFR DAVGVLFFGG VALSSRGALY
VDGLSVQTAL GLCVSVEGGV VAGGGSVVAF VDSDFLLCKH AVSVRGAVSV SGSAVALVRS
EFSSTEDYAV AFYSTVRLAG GSMLLAKGNV HDGVSREMLY AAGTVTAAGS TLSFVRNRAL
LPRMLSLSLS LAAGAHLRVA CNDAGGRVLL TAEEYAAAGF GDAGSIEVVG CDACDRDTHC
YAPGTASASM KDGVCVCVCG SGGYGEACLP VGAPALPPAV GTAPSVFVRE GVTVQSVFVV
PAGASEVTLR HVVLDGVSSV LYVPWMARDG VRIVVQNVSL LNGAVLYVMG GGALRGAVSA
GSDEGGPVEL SVCDVEALNG ALVLTGTFPA GSVLTVTDSL LVAARPTPLV YLPGSQSSPY
APVLVLSGLR LVRSVLVVSG VALVTVMTGG RTVVVDGAVL ELVGGGVALD AAVFGGEYAL
YASARVVASG GAVLRVSGSQ VYAAHGLVFG SGVEANASAV VVNDNAGALT DGALLELRGS
ASFVSGSWLS VRGNSISGRL LSLPSYPRRA EVMQSILTLY GNAGSGHVVM DGTVALVGAG
RRFFVGCLTL NGRALHPMDY RSAGIVGKFR PVACGVCDAD VSCFAAATRT MSGSCRCRCA
EGGYGRDCLP VYLPHVDGCN RTSAMPPLSR TEMLTETRSP IPTWTLGPIP TWTPTPTEYG
PTETLQVTET LALSPTRTPT ASVSSTLWWS EVACPTLAVT TTAAGGSLTQ NDIRGGGSAV
PTRLMVALPP PFRWARDPQL CTHLSFVPVS TAQPRGFGGP WGAMLRNATW VRNATNPSTV
LELAVPVHRG YFIVADETIV IRCGAAAVSG GCKGLLLGSF TIRSDTLPVA ASALSAITGV
VAGAAAVAVV VTGGLGSVLE MQALGVFARM SCASAQERAS TVALPYFLSV FAALDPLWMV
VGNALLAAVF GCVHCGVTAA FQRWRGVDAA SAWAAMRFPS LTYVVAHAMH LGIFFGSVLA
LVMPGARVQH YVIGVVGVLY GAAFPAGVCY FIARHTGASF TRYWQFSRKP LHERLLYPVG
YWHPAAQQRM YGGMLTNMRG SRVYWCVFQL SVLCVVGLIA AVHPPVGGCH VQYFCMAAVL
LAGAGVVAFT NMMRSAFLTV MHTASLVLLA ALCVVSAANH LEPSDGGARA YVATVLLLTT
VLLAVTVYGV VVWYVEDRHW QELREPRRGG LGALLRDDED GDEETQKLHE MTSLSYASGT
TVSSSYRPPA QLQPMAGDTR SEALSPLDRA SSASHMIGYA AI
//
