ID Q4DL48_TRYCC Unreviewed; 815 AA.
AC Q4DL48;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=Tc00.1047053509029.160 {ECO:0000313|EMBL:EAN93264.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN93264.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN93264.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN93264.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN93264.1}.
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DR EMBL; AAHK01000365; EAN93264.1; -; Genomic_DNA.
DR RefSeq; XP_815115.1; XM_810022.1.
DR AlphaFoldDB; Q4DL48; -.
DR STRING; 353153.Q4DL48; -.
DR PaxDb; 353153-Q4DL48; -.
DR EnsemblProtists; EAN93264; EAN93264; Tc00.1047053509029.160.
DR GeneID; 3546757; -.
DR KEGG; tcr:509029.160; -.
DR eggNOG; ENOG502QPTM; Eukaryota.
DR InParanoid; Q4DL48; -.
DR OrthoDB; 132659at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR CDD; cd00821; PH; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 390..485
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 114..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 91828 MW; 086D96A95F1B78C2 CRC64;
MNLGVDARFP LDVSFDILRR VLDEESLVLA QLAYIVGHLH DPILQSCGHG NVATGPWRSH
GNNKSNAVGT KQQPAILRFA QYWELFANIA TLHGAQSTIV GKLEEVVNNR THLLDQQEEK
KKEVKSGHGA AKNLHMRSSS SSSSSSDGGT DEGMRGPQSI LELFCSAAMR HYIAEHMMYS
LNYSRNIAPR VMELWRLWRC RCGKNTSAHL SARERQELES YMGFLYFLWH AFGGEDGVPD
DPRVIFTRLP ETLLVKSQRP KKDRTGHNTA VVPVKMPDAP SIPPNWRGFE TLLVLLATPL
ASLRRYMHVA RCIIESQSLP IPVRQRLQVD FVDLLVLRLA EEHSIVFDEL AKQDISHIMA
LIDEVSPPAP SEAHKKKFPR IRLDEDGSRT LVHYGRLIKR FRRGRHERLV FLFSDWLCYV
EEQTNGRMRL RASISLESLR VVELDDTAEV VNGFDIVTKD MRLTFFAPTL EQKRQWVDAL
RNTTEAYKVK VQQLASPRRQ DISQQQQQQQ QNKSLGHLAC QTRVTALPLS HNSRLRRQQR
ADHALQRRLE RRSTAELATT NSLVADETPA HVMGIDAGRK QPALSFRPLH GNFDVTYWAQ
QSTETVHKRV RSSDLLRSSW ALQSPHDPNA CEPKAVAPGM DPLNHGNIST TTDAADCSVH
SADAPASAGH SPTSPWVPPR AVLSRLLSER FQEPSLHPLY SGGNANSPLP ENVSENEGRE
EPDSLYTTLL SCVATTEVHK YSFAAEEDEV VLENDEWVPT CDETPDAIRP EGPAVHISLK
HLVGETDSDH GSNSQSHSNH FEEEEEEEEA MWSPR
//