ID Q4DTN0_TRYCC Unreviewed; 784 AA.
AC Q4DTN0;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Spindle pole body component {ECO:0000256|RuleBase:RU363050};
GN ORFNames=Tc00.1047053511211.150 {ECO:0000313|EMBL:EAN95885.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN95885.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN95885.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN95885.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|RuleBase:RU363050}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN95885.1}.
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DR EMBL; AAHK01000184; EAN95885.1; -; Genomic_DNA.
DR RefSeq; XP_817736.1; XM_812643.1.
DR AlphaFoldDB; Q4DTN0; -.
DR SMR; Q4DTN0; -.
DR STRING; 353153.Q4DTN0; -.
DR PaxDb; 353153-Q4DTN0; -.
DR EnsemblProtists; EAN95885; EAN95885; Tc00.1047053511211.150.
DR GeneID; 3549798; -.
DR KEGG; tcr:511211.150; -.
DR eggNOG; KOG2000; Eukaryota.
DR InParanoid; Q4DTN0; -.
DR OMA; FVNNLWS; -.
DR OrthoDB; 197975at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF72; SPINDLE POLE BODY COMPONENT; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 187..466
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 473..773
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 80..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 88003 MW; 4A886DB0C64D1EEF CRC64;
MSDGGGGGGG GGGREFFFPS KLPKVENGIF LPREGSPRVI PFRAATQLRG AGAVQHSSSG
VASSVVPVPS VEQVVGGVLR RGEEDRSAPG EDVGGTNNSV EDKNCGGFEL PGRIFCRRDR
SSADAAGVRQ AAASSKTVAV VTGVMPRYRD TMQPNGDAME CMPHEGDGSP TCAVGHTCVA
VEESEFISDV LFMWMGVEKT KYFTYDATSH RYVMSAEVGT MRQRQAFLTL QECGWLAHQI
DEVLRSTTTE RSFLQQSLRS AMRQQLLQYH CLVASFRERR LPPMTFSDLV VAFKRVQPKL
QVLFTILRET ESVKGGELAS KLQRLVQQGS TRLYALLSEV YMEAVSPLLY MAVSSITKGE
ISDPFNEFFV KSNPRIDNTS DAFWSSKFAL LPEMLPTTVS RALAEQVMLV TKNVSFIRNC
CRCKQWHMDP AIVTAAQGAS FDTIGAVVRD AMCFTNTAVL KLIREEFHLD NVFRMVNAFL
LVGNGGFYEL LIDRLDPVLS RLSHMVQTSI VRDHMQSALL DIVPYTRHLD TDLFSMLQCE
MVKDDKIIGW DAFLVTMTVP SPLNNIFDVT AMKVYRRLFR IMFKVKRAEV ALKKSWRQSV
VLDRIIGRLH NTSREVIAWR EVAADAHLLG LQLNHFVNNL WSYLVAEVST VSWDLLMKAL
RQCTSLDEIR AAHIAYLQYL TLHSLLHGDC ASMRQNIESV LSIVRQYVGA QALLTSLLER
GNGDVFSIKS EYQRLTDDFQ REITSLLTTL EEQHLQFDFL NFLLLRLNFN HFYHDTMFGN
NTEF
//
