ID Q4DTQ7_TRYCC Unreviewed; 475 AA.
AC Q4DTQ7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE SubName: Full=Epsilon tubulin, putative {ECO:0000313|EMBL:EAN95909.1};
GN ORFNames=Tc00.1047053509695.120 {ECO:0000313|EMBL:EAN95909.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN95909.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN95909.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN95909.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN95909.1}.
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DR EMBL; AAHK01000183; EAN95909.1; -; Genomic_DNA.
DR RefSeq; XP_817760.1; XM_812667.1.
DR AlphaFoldDB; Q4DTQ7; -.
DR SMR; Q4DTQ7; -.
DR STRING; 353153.Q4DTQ7; -.
DR PaxDb; 353153-Q4DTQ7; -.
DR EnsemblProtists; EAN95909; EAN95909; Tc00.1047053509695.120.
DR GeneID; 3549837; -.
DR KEGG; tcr:509695.120; -.
DR eggNOG; KOG1375; Eukaryota.
DR InParanoid; Q4DTQ7; -.
DR OMA; KRAHLHH; -.
DR OrthoDB; 5480452at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02190; epsilon_tubulin; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR004057; Epsilon_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF13; TUBULIN EPSILON CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01519; EPSLNTUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 44..268
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 270..415
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
SQ SEQUENCE 475 AA; 52310 MW; 47B3027F19F846F0 CRC64;
MPREIVSIQV GQCGNQLGLK WWDVMMQEQK ANPQYPDARD ALFISEPVGK DGSVTLKARC
VAIDMEEGVL RSMLRGPLQG LFDATFFVSD VSGAGNNWAV GHMEYGDKYI DSISDSVRGQ
VECCDSIQSF FVMHSLSGGT GSGLGTRVLG MLEEEFPHIF RICPVVMPGA VDDVVTAPYN
TAFAVRELIE HADAVVPLDN DALSRMADSA LGRKSMHNAD GEILRGGVPD VHTYSVAEPT
KTKLPYDSMN AVVAQLLSNL TCAMRFPGPL NMDINEITTN LVPYPRLLFL TAAIAPLNVA
RYSVAAGPRS IDTLLASCLE KDHQYVDVSG GTKSALTKDA GTCLATALIA RGPQITVGDL
ARNIPRIRER QKLVYWNEDG FKTALCSVSP LGHRDSVLML ANHTSIAQKL ETIYERFTRL
YNVRSHVHHY ERFLELSYFD ASAEILSTTV DDYNFLNTEE PPTDVPQSMR ELVYY
//
