ID Q4DUN8_TRYCC Unreviewed; 861 AA.
AC Q4DUN8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN96245.1};
GN ORFNames=Tc00.1047053510713.160 {ECO:0000313|EMBL:EAN96245.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN96245.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN96245.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN96245.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN96245.1}.
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DR EMBL; AAHK01000163; EAN96245.1; -; Genomic_DNA.
DR RefSeq; XP_818096.1; XM_813003.1.
DR AlphaFoldDB; Q4DUN8; -.
DR SMR; Q4DUN8; -.
DR PaxDb; 353153-Q4DUN8; -.
DR EnsemblProtists; EAN96245; EAN96245; Tc00.1047053510713.160.
DR GeneID; 3550260; -.
DR KEGG; tcr:510713.160; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DUN8; -.
DR OrthoDB; 132268at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..459
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 92980 MW; 41FD5B6C2B73B797 CRC64;
MFSRVAAVKA PRTQNRRCVT GSSGRRREGR ESEPQRPNMS RHLFYSAVLL LLLVAMMCCN
AGGAQQTIKT APDPRSLPKT YFVWRDKKGE ETVVYLRVPS LVEVKGDVFA VAEAPCKDGG
EKAFTGIASE VLTLSDEESK ELDKNAVKTQ VLEECAFDKK SGCHIAGQDD SKTQTRVLLS
RPTTVVKGSD IYMLAGNYSW TLAAGVQGAD AGDWGLVLVK GNVSNEKSQK RIFWNDTYAI
PWNYNKKNES LALLVGSGGS GVKMEDGTLV FPVEGTRKKT TNQVGTEEDE KTVSLIIHSL
KDTNSWTLSK GMSDGGCSDP SVVEWEDKKL IMLTACGDGC RRVYESGDKG ESWTEALGTL
SRVWGNKQGE GGVRSGFITA TIDDVDDKRN VMLVTLPVYP EKADKKEAGN GKSELHLWLT
DNTHIVDIGP VSGDDAAASS LLYKSDGSGD KKELIALYEK KKDGEESSPS MVSVLLTEQL
QRVKDVLATW KKVDDLVSEL CPSESDVESA SPEDACSTTD VKITDGLVGF LSGNLSENTW
RDEYLGVNAT VKKKEDAGET GATNTSDGVK FRGAWAEWPV GKQGENQLYH FANYDFTLVA
TVSIDKVPQG DTPVPLLGVH LEGKDKLMEL SYDSEKKWQV LCSDGKIKKL KSTWATEIQH
QVAIVLRNGT HGTAYVDGKR VCVDAQRSSD NTEGKKISHF YIGGDGGSAD NTRSREDVSV
TVRNVFLYNR PLTFSGGNAN LEEDSDSPSA DQEPSAEPAS PFVSTDKNVA PSVGELPEAP
VEPTTPQQPQ QERETQKSTT VGTSATTQEV PANTSQGSVG KAAASNSHAI GEASGDAVTV
RGSGLLPLLP LLLGLWVFAA L
//
