ID Q4DUP2_TRYCC Unreviewed; 884 AA.
AC Q4DUP2;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN96241.1};
GN ORFNames=Tc00.1047053510713.90 {ECO:0000313|EMBL:EAN96241.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN96241.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN96241.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN96241.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN96241.1}.
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DR EMBL; AAHK01000163; EAN96241.1; -; Genomic_DNA.
DR RefSeq; XP_818092.1; XM_812999.1.
DR AlphaFoldDB; Q4DUP2; -.
DR SMR; Q4DUP2; -.
DR PaxDb; 353153-Q4DUP2; -.
DR EnsemblProtists; EAN96241; EAN96241; Tc00.1047053510713.90.
DR GeneID; 3550256; -.
DR KEGG; tcr:510713.90; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DUP2; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 93..447
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 93836 MW; 7C8C674F47BCDB5F CRC64;
MLSRVAAVMA PRTPNRRRVT GSNGRRREGR ESEPQRPNMS RHLFCSAVLL LVLVMMCCGT
GVAHAEVQPS QKKFEWKVIK DEGGGVTVES LGAPGLLKVG SDVFAVAEAK NKEKNGQGSF
TGIASQLLTE TEEKKDNTPV EVLKDPKDTK FLEEDGSADS KKKVDVSRPT TVMRGNEIYM
LVGKYSQAAA SDQDRVANDG GLLLVQGSVC DEGGSGKRIK WKDNDGVSRI SVGELDSWTG
LTGGGGSGIE MEEGMLVFPV EGKKKEKGGS NDGKTVSLLI YSSEDTNKNW NLSRGMSDGG
CGDPSVVEWK DKKLMMMTAC DDGRRRVYES GDKGESWTEA LGTLSRVWGN KKGEGEKGVR
SGFITARIDG DENNRNVMLV TLPVYSEKAD KKETDNGEKG VLRLWLTDNT HIVDIGPVSD
DDAAASSLLY KSAEGGTDKK ELIALYEKKK KGDEKPSPGM VSVLLTAQLQ RVKEVLATWK
KADDRVSKLC PSSDVEDAST GDACSPIVRI TDGLVGFLSG NFSDGTWSDE YLGVNATVKN
NDDGGDKATL HAGGVKFTGA WAEWPVGAQG ENQLYHFANY NFTLVATVSI DKVPEGSTHI
PLMGAKTNSA ENTVLLGLSY SNNEKKWMLL CGSGNRKELS SALEPGKTRQ LAIVLQNGSQ
GSAYVDGQRV GVGDAPCELK VTEPNEISHF YIGGDGNSAG GAGSQEGVSV TVTNVLLYNR
PWTSEEIGAL NPNKDTITSP MTENAPETML QSPAKPQPSE DEPLKENIGA GVLSSAASTA
TTVSSDFAQE AATGSGDTML GNGSPQTPEE SVSSGEDGED GETAEGTDVQ GEGIHSQGRE
VNAAALSSSL GNVSQGNNSD ACTVRGSRLL PLLLLLGLWG FAAL
//
