ID Q4DUU1_TRYCC Unreviewed; 261 AA.
AC Q4DUU1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Thymidylate kinase-like domain-containing protein {ECO:0000259|Pfam:PF02223};
GN ORFNames=Tc00.1047053508501.250 {ECO:0000313|EMBL:EAN96299.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN96299.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN96299.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN96299.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN96299.1}.
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DR EMBL; AAHK01000160; EAN96299.1; -; Genomic_DNA.
DR RefSeq; XP_818150.1; XM_813057.1.
DR AlphaFoldDB; Q4DUU1; -.
DR STRING; 353153.Q4DUU1; -.
DR PaxDb; 353153-Q4DUU1; -.
DR EnsemblProtists; EAN96299; EAN96299; Tc00.1047053508501.250.
DR GeneID; 3550309; -.
DR KEGG; tcr:508501.250; -.
DR eggNOG; KOG3327; Eukaryota.
DR InParanoid; Q4DUU1; -.
DR OrthoDB; 168156at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0050145; F:nucleoside monophosphate kinase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR014505; UMP-CMP_kinase_2.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF5; UMP-CMP KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR PIRSF; PIRSF019736; dTMP_TKRP1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 56..214
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 261 AA; 29401 MW; F09CE78AD4D703BA CRC64;
MINSVYHSKK ACVEALRAVE RLQPSWWTPP CSEFLHRVEQ TPTVTAQPNQ KTLIVLEGID
GVGKSLVAQS LIEKLGDSAV LIRTPHPDLS GIRETFRAQT EETARAFYSA ANYLAAWDAF
HATKERKFVV FDRWWCSTCA MALANSCRLA ALPAAGDAVY QWPQDLPPFQ LGALLYVEEH
IRQARIRQRA PEDAEERRLR AQQEMREVAM EAYRRFGLLN EVHVATYGVA VNRILALMTE
KGLPHSATPF SAEELAALRQ I
//
