ID Q4DUZ6_TRYCC Unreviewed; 681 AA.
AC Q4DUZ6;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Cell division cycle protein 45 (CDC45), putative {ECO:0000313|EMBL:EAN96366.1};
GN ORFNames=Tc00.1047053506811.210 {ECO:0000313|EMBL:EAN96366.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN96366.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN96366.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN96366.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC45 family.
CC {ECO:0000256|ARBA:ARBA00010727}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN96366.1}.
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DR EMBL; AAHK01000157; EAN96366.1; -; Genomic_DNA.
DR RefSeq; XP_818217.1; XM_813124.1.
DR AlphaFoldDB; Q4DUZ6; -.
DR STRING; 353153.Q4DUZ6; -.
DR PaxDb; 353153-Q4DUZ6; -.
DR EnsemblProtists; EAN96366; EAN96366; Tc00.1047053506811.210.
DR GeneID; 3550385; -.
DR KEGG; tcr:506811.210; -.
DR eggNOG; KOG2475; Eukaryota.
DR InParanoid; Q4DUZ6; -.
DR OrthoDB; 126750at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR InterPro; IPR003874; CDC45.
DR PANTHER; PTHR10507; CDC45-RELATED PROTEIN; 1.
DR PANTHER; PTHR10507:SF0; CELL DIVISION CONTROL PROTEIN 45 HOMOLOG; 1.
DR Pfam; PF02724; CDC45; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000313|EMBL:EAN96366.1};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT REGION 176..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..208
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 77636 MW; 61186325667D5CD7 CRC64;
MADQLTPWEH INRFYHTTRK PIQLLVAYHA DAAAASITLT TLLKACFVPF NLHPVMEYEE
VKGVIQRTNM TQDAEISDGG APVDELFVLI GLGAPVSLRS FFDLRRHIVI VLDSYRPFLL
DNLRASDNNR LVLWGHERIH EEVEQFFREQ RKRELARARR RRRRRTRKNQ RRLRAYGELV
NDDDDEEREE ESEISSGSSD DGDDDENHDD MTPSQSQEGI DWMNEEVPEN LEQLYYAAER
GGKSCALEVY DLAILLNRVK EAVLWHAAVG VCDLFTRRLI DYGTYLVEMR RLHNEVTLRK
GIRRGPLDDV TEETVNRHHK IASSNTMQLV NLDEDQLFLL RHYSLWGAMW YHPVVASLLG
LHHVEDGTGT LRQLLARCGV SAKLAQQPWG EIPDDVRVDS LRLVHHELKQ ALKTRGSFVK
WPTRIWCVAR TTGYSVEVST FDVCTLFTAL LAKVPPGAMN TEEASEESMK EKLREFRREQ
FWRAHDVIDA DPNSNLFVAA VQEAKMLQES VATATSALMQ PGMIQSTKGI HYTQPSDPTN
ASTALETFGC PFRIAVLAEH MLFALTVERG LGKYTREVRP VLLSCPVSRL IGLNSQQKQK
EEVIQSEEAF IVLFAHEGPT KEGLSPVLPV ARWNECVTNT EDFLVPPLRD FIRRDTVIVD
GRESTAHLGE MLHLRSLTAA L
//
