ID Q4DVI7_TRYCC Unreviewed; 1059 AA.
AC Q4DVI7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN96543.1};
GN ORFNames=Tc00.1047053506961.150 {ECO:0000313|EMBL:EAN96543.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN96543.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN96543.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN96543.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN96543.1}.
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DR EMBL; AAHK01000144; EAN96543.1; -; Genomic_DNA.
DR RefSeq; XP_818394.1; XM_813301.1.
DR AlphaFoldDB; Q4DVI7; -.
DR SMR; Q4DVI7; -.
DR STRING; 353153.Q4DVI7; -.
DR PaxDb; 353153-Q4DVI7; -.
DR EnsemblProtists; EAN96543; EAN96543; Tc00.1047053506961.150.
DR GeneID; 3550642; -.
DR KEGG; tcr:506961.150; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DVI7; -.
DR OMA; CYNPSIV; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR022144; DUF3676.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF12429; DUF3676; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 101..436
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT DOMAIN 742..971
FT /note="DUF3676"
FT /evidence="ECO:0000259|Pfam:PF12429"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1059 AA; 114162 MW; C91A39751F5BE5E4 CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGR ESEPQRPNMS RHLFTSAVLL LLVVLMCCGS
GAAHAEQAGA AVDPFTGTTP ISFANWKEFN EAGGKITSHR VPGLVKVGDD VFAVAEAQCG
ERNEAGSCAG IVSKHLDISD DSMDISTSDI SLFRMQLGDT IENNFGATEV LRPTTLVLGD
SVYMLLGNHS LTKSQVVGKN ERGLLLVKGT VTVDGGNKKK LVWNETHVVN PQRKGESRSL
TEFLGGGGSG AVLRDGTLVF PMQAKGRDGT RVLLSMRFDP SDKKWELSSE TPGNGCMDPT
LVKWEKYEGD ERLFMMAHCA GGHYDVYKST PEGANWYPSG EPINRVWGNS HNRKGYGVQS
GSTTAIIEEK EVMLITAPVY PKDNKGGKGR LHLWVTDTSR VYDVGPVSRE SDDAAASSLL
MKGGKDNKEE LISLYENKKG DGAYSLVAVH LTEKLERIKE VVKTWKDLDS ALHSCHSGSS
VTVDLPTKGM CNGRVPTDGL VGFLSGNSTG TEWRDEYLGV NATVHGPAEK RREVPNGLTF
KGPGAWAVWP VGDMGQTVPY YFANNEFTLV ATVSIHEVPI ESSSPIPLMG VRMNDTKGTV
LFGLSYTHDR KWLAISENSG NVEDLDDAED PGNVEDVVEW EPNETYQVVL QMDYYYWTVV
VNREEIHKTK YNTSLFNSHR ISHFYIGGDS KDQSATGGHV TVTNVMLYNE LFDDNLYELH
ASKVTIPSLG VEKQPTEQAA NTGALVASES NSEESATSHE ELNEGDTDEQ EEENVLNLVP
AVSSSTVAGG SSVPEPAIAT EIAGNSRSED NAQLSEGETS QQTTLNEDNE SMQRDSEMQT
QELQSEESTE ATDFEGSSES YGTEQPVEEG GTNGRSGGSV SSGAASSDMD TVAAPVYGEH
QVQQITEPSA ENDDVRSTGT VTTGAEESFS LETGDRNSER TMGSDSSPTP SKSDAEPTSA
EDTDNISRTD GAEVSSEDGK EVPRTVDTAP ENTNTTPGES KIPSESNATT PSDTDILLEH
GHLGELAAIS LIGDITVHGC LSRVLLLLLL GLWGTAALC
//
