UniProt: Q4DXL4

Database: UniProt
Entry: Q4DXL4_TRYCC

LinkDB:  Q4DXL4_TRYCC 
Original site:  Q4DXL4_TRYCC

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Ontology (4)   
   GO (4)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (9)   
   Pfam (3)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (22)   

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ID   Q4DXL4_TRYCC            Unreviewed;       977 AA.
AC   Q4DXL4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN   ORFNames=Tc00.1047053506195.120 {ECO:0000313|EMBL:EAN97254.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN97254.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN97254.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN97254.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN97254.1}.
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DR   EMBL; AAHK01000107; EAN97254.1; -; Genomic_DNA.
DR   RefSeq; XP_819105.1; XM_814012.1.
DR   AlphaFoldDB; Q4DXL4; -.
DR   SMR; Q4DXL4; -.
DR   STRING; 353153.Q4DXL4; -.
DR   PaxDb; 353153-Q4DXL4; -.
DR   EnsemblProtists; EAN97254; EAN97254; Tc00.1047053506195.120.
DR   GeneID; 3551496; -.
DR   KEGG; tcr:506195.120; -.
DR   eggNOG; KOG1959; Eukaryota.
DR   InParanoid; Q4DXL4; -.
DR   OMA; WIYQINR; -.
DR   OrthoDB; 5474711at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR   Gene3D; 2.60.40.1360; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW   Signal {ECO:0000256|RuleBase:RU361199};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|RuleBase:RU361199"
FT   CHAIN           24..977
FT                   /note="Alpha-mannosidase"
FT                   /evidence="ECO:0000256|RuleBase:RU361199"
FT                   /id="PRO_5017850292"
FT   DOMAIN          354..426
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   977 AA;  111247 MW;  71876E63C86F9AD6 CRC64;
     MRLLTALFAY FIVALILAFS VSAKHTVHLV AHTHDDMGWL KTVEQYQYGL NNTIQVADVN
     GIISSVIAGL LLNPRRKFTY VEIGFFSRWW KEQGEEMRNT VRNLVAKGQL QFANGGWCMH
     DEATTHFIDM IDQTTIGHRW LWRELKVVPR VGWQVDPFGH SATQAAMLTA RAGLVGTFFA
     RVDYRDFEYR ASTGRRQFWW QPSPSLPELQ TFAEINLHQT YCPPSKFSWD VVDYWMSAVR
     NTDPLNFVED KSSENYNIPF ILELFKEEVR RNVEQTRGKN IMWTMGCDFN YFASELWFGK
     MDRLIEIVNA DGEFEVRYST PYEYAMAKRE EHSKGIVYDT KKGDFFPYAS APHEYWTGYF
     SSRPALKRLV RRLSSYWTAA RQVEFLAGVP TGEVPMLSDA LAIAQHHDAI TGTAKQHVAF
     DYAKRLTEAY KEDLSVRLRP ALSGCPFGFE NAQHCLLSNV SVCSATAKAF EKEGAVVNVL
     VWNPNAHSVQ RTIVHIPVPR SDVIISGEGV LRYSVFESPV QISDYANENK EWQPYTLGVE
     LQLVKLTILN LFTPQLKFAT KKHTSRLVSL VRPSEDDLEI SNEALVLKFG RNGLIESVTV
     RSSGQTVAVK QDWCYYISNN GDTVSSSPGG AYIMRPVSNA TCNPITDSPV ELRLVDRRMG
     VVEQRFGKDL LQRVILRGDL VDVEFTSFGI PIHDNFGREL VARFRTSVES GDVFYTDSNG
     REMQRRRVDH RSDYPFTQTE PVAGNFYPVT SVFFINDTQT QFNVFPDAPM GGTSLQSGEV
     LFVVHRRLLR DDFKGVEEPL NETAFVTSYA DCVMANTSNC GHHYGPPLRV RGTLSFSVSR
     SGPTAMRRVR EQQDENYYTP LVMFSSSSTD AASAIARYNT SFGFSLPPSL QVVTLQLIDQ
     QKLLLRLGHR YAVSEDPERS LPVEVDLMTI FKEFHWITIL SIDEVSLTAV EIVQRQIQKV
     TVRPMDIRTF IFYIKAH
//

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