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Database: UniProt
Entry: Q4DY50_TRYCC
LinkDB: Q4DY50_TRYCC
Original site: Q4DY50_TRYCC 
ID   Q4DY50_TRYCC            Unreviewed;       852 AA.
AC   Q4DY50;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   07-JUN-2017, entry version 44.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Tc00.1047053511727.90 {ECO:0000313|EMBL:EAN97434.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma;
OC   Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN97434.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN97434.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J.,
RA   Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T.,
RA   Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D.,
RA   Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H.,
RA   Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R.,
RA   McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S.,
RA   Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U.,
RA   Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L.,
RA   Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E.,
RA   Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N.,
RA   Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAN97434.1}.
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DR   EMBL; AAHK01000099; EAN97434.1; -; Genomic_DNA.
DR   RefSeq; XP_819285.1; XM_814192.1.
DR   ProteinModelPortal; Q4DY50; -.
DR   STRING; 353153.XP_819285.1; -.
DR   PaxDb; Q4DY50; -.
DR   EnsemblProtists; EAN97434; EAN97434; Tc00.1047053511727.90.
DR   GeneDB; TcCLB.511727.90:pep; -.
DR   GeneID; 3551696; -.
DR   KEGG; tcr:511727.90; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   KO; K02154; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002296};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    394    419       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    431    454       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    516    538       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    550    573       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    612    635       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    793    815       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      106    133       {ECO:0000256|SAM:Coils}.
FT   COILED      246    280       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   852 AA;  96271 MW;  84F90593FCC650A3 CRC64;
     MPREGASGLW RSEDMIRLDV ITQREVLYET VVCIGLLGKA KFVDVNNDVT AFSRHFTTEI
     RRYDEMERKL SIINGELARE RELVEACSPS LDAHDDVKRI LCSTMIEEDE EKVDSLVEEL
     KRVNASLQGL RSEMNFRLEL SLLHTRLQDL VSSQFSQPSV AFLQTSHLLG MVDAARAEAM
     YAMAYRATKG NVLIELDNKP AMLLDPITGE RCIAKTPFAI FAPSPGLLKR VERLVLTLGA
     TVHSLRDVSQ AKMEGQHREM EELQEMYDRM HVRKLELIQQ HARIYHELLR IVRMKKKVFT
     IMNLCVVSGS TCTASVWIPK KHEHTLRAAI REAVHASAGE VFSVVTLHSS QRNPPTFFDT
     NKFTQCFQSI VDSYGAARYK EINPGVFTIV TFPYLFGIMY GDIGHGMLLL LFAFYLILME
     NRWNRCQLNE ILAMLFGGRY LLLLMGVFSI YMGALYNDFF GFSVGLFSSA YAWPPIGEQN
     GTVHPLGEKN RTGIYPMGLD VAWAETENKL EFYNSVKMKC AVIVGVVQML TGNVLSLFNH
     IYNRELHKAI FLFIPEILFL LCTFGYMSLL IVVKWCTRWE NTSEAPSILE TMTNFFLQPG
     IVSQPLYNGQ KWVQILLLLT AFAMVPVMLL VMPLIEVRKH REEYLGYRLF LDSVSLPAIN
     GSDSKTSEDP IVTVSTARRN EFPVASLENT LGSHLGMGWE NNHTEDTPLG HASYGTGAAP
     ADYDDYEGGN RLDSSEVFIH YVIHTIEYVL GCVSNTASYL RLWALSLAHA QLSEVFFNFA
     VVKVLGMDTT GVFIAAGIAI WLAVTLAVLV GMEALSAFLH ALRLHWVEFN NKFYVGDGVA
     HEPFDLLDYL EY
//
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