ID Q4DYQ4_TRYCC Unreviewed; 456 AA.
AC Q4DYQ4;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=T-lymphocyte triggering factor, putative {ECO:0000313|EMBL:EAN97677.1};
GN ORFNames=Tc00.1047053507641.210 {ECO:0000313|EMBL:EAN97677.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN97677.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN97677.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN97677.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the DRC4 family.
CC {ECO:0000256|ARBA:ARBA00009859}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN97677.1}.
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DR EMBL; AAHK01000090; EAN97677.1; -; Genomic_DNA.
DR RefSeq; XP_819528.1; XM_814435.1.
DR AlphaFoldDB; Q4DYQ4; -.
DR SMR; Q4DYQ4; -.
DR STRING; 353153.Q4DYQ4; -.
DR PaxDb; 353153-Q4DYQ4; -.
DR EnsemblProtists; EAN97677; EAN97677; Tc00.1047053507641.210.
DR GeneID; 3551983; -.
DR KEGG; tcr:507641.210; -.
DR eggNOG; ENOG502QQDA; Eukaryota.
DR InParanoid; Q4DYQ4; -.
DR OMA; VEMKVYK; -.
DR OrthoDB; 150400at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0048870; P:cell motility; IEA:InterPro.
DR InterPro; IPR039308; GAS8.
DR InterPro; IPR025593; GAS8_dom.
DR PANTHER; PTHR31543; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR31543:SF0; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13851; GAS; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 217..415
FT /note="Growth arrest-specific protein 8"
FT /evidence="ECO:0000259|Pfam:PF13851"
FT COILED 111..138
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 174..224
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 271..365
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 456 AA; 54363 MW; 66B5D215F42C1B4A CRC64;
MPPKAVRAGM RKADKVPPPC DPIAELSSLE SIHEALKKAQ ELRNYFQVER DKVNEFWSVS
KKELENCRHA ILNADAELEE MERAHQVEMK VYKQKVRHLL YEHKMKVKHC KEESDRLLRE
AEERHQKRMN EIQSQLTQHD RHFEAAMESH EMRIEDQRDS QNYMLTVTKK QKHEKDLARQ
TALYEAKLKT LRDELELRRR AEIHEIEERK NEHINALIKQ HEAKFQEMKE YYNHITTNNL
EIIQSLKEEI AQMKKNDEHN ETLMYDIDCE NQNLVAPLEE AQREVAELQQ KRKQYEQDKR
SLGTTRAKLR SLREEIWRLR KEHKDLEERY AEVHREREEL KAKFESALRQ AMEVVEERNE
VLQQKLVESH ALVEERDAQL DGVLQAMNLE PTALELIASE VDSTLKQKNQ MIRDLHFELK
KGEKLVNTTL VELERRCQAV NIPPLSREQF LTARVV
//
